List of All Articles with Tag 'tech'

Salesforce Inc. Chief Executive Officer Marc Benioff said he pushed San Francisco officials to clean up the city

Square Enix Holdings Co. has shed nearly $2 billion of its value since Final Fantasy XVI, the latest

Daniel Zhang, the outgoing chairman and CEO of Alibaba, has stepped down from his position running the company's cloud division in a surprise move announced just months after he assumed the pivotal role.

To block microwave radiation, all you need is a simple screen.

Scientists in Israel have created a model of a human embryo from stem cells, without using sperm, eggs or a womb. A team at Israel's Weizmann Institute of Science made the model, which resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, and the work was published in the journal Nature. But the scientists involved said it would take a long time yet to create an embryo from scratch. Team leader Jacob Hanna said the team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state.They then manipulated them to make a model of an embryo, rather than an actual or synthetic one. "The question is, when does an embryo model become considered an embryo? When that happens, we know the regulations. At the moment we are really, really far off from that point," Hanna said. However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and maybe grow transplant tissues and organs. "They are not identical. There are differences from human embryos, but still, this is the first time, if you open an atlas or a textbook, you can say - yeah I can really see the similarity between them," said Hanna. "In about 1 percent of the aggregates we can see that the cells start differentiating correctly, migrating and sorting themselves into the correct structure, and the farthest we could get is day 14 in human embryo development," he said. Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50 per cent success rate. Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

As of Tuesday, it’s gotten much harder to find an Airbnb rental in New York City. That’s because

OpenAI Chief Executive Officer Sam Altman is the first person to get an Indonesian golden visa as Southeast

The federal government is reportedly investing at least $22m into developing clothes that “can record audio, video, and geolocation data.” According to a 22 August press release from the office of the Director of National Intelligence’s Intelligence Advanced Research Projects Activity (IARPA), the research and development arm of the organisation, “recently launched a cutting-edge program that aims to make performance-grade, computerized clothing a reality”. The DNI touted the SMART ePANTS program, which stands for Smart Electrically Powered and Networked Textile Systems, that “seeks to develop clothing with integrated audio, video, and geolocation sensor systems that feature the same stretchability, bendability, washability, and comfort of regular textiles,” IARPA stated. They will be used by the intelligence community, IARPA wrote. Since the surveillance technology will be woven into the clothing, “Intelligence Community staff will be able to record information from their environment hands-free, without the need to wear uncomfortable, bulky, and rigid devices.” For example, according to the release, the technology could “assist personnel and first responders in dangerous, high-stress environments, such as crime scenes and arms control inspections without impeding their ability to swiftly and safely operate.” The SMART ePANTS program’s mission is to to incorporate “sensor systems” into clothes, like shirts, pants, socks, and underwear. The Intercept reported that the federal government has dedicated at least $22m in funding to the program. It’s unclear just how big of a gamble IARPA might be making with its investment. Its website describes itself as investing “federal funding into high-risk, high-reward projects to address challenges facing the intelligence community.” “A lot of the IARPA and DARPA programs are like throwing spaghetti against the refrigerator,” Annie Jacobsen, author of a book called The Pentagon’s Brain about ​​the Defense Advanced Research Projects Agency, told the outlet. “It may or may not stick.” Dr Dawson Cagle, an IARPA program manager leading the SMART ePANTS program, said that while he is “proud of the intelligence aspect” of the program, he’s “excited about the possibilities that the program’s research will have for the greater world.” He said that he was inspired in part to create the program by his father, who was a diabetic, and therefore had to monitor his health multiple times a day. His father’s experience paired with the research that supports that the components of a computer “have already been developed, just as individual pieces,” he explained. If you can convert all of the components into a single, wearable device, the program’s goal will have been achieved, Dr Cagle said. Ms Jacobsen warned that the advancement of smart wearables could lead to future concerns over biometric surveillance by the government. “They’re now in a position of serious authority over you. In TSA, they can swab your hands for explosives,” Ms Jacobsen told The Intercept. “Now suppose SMART ePANTS detects a chemical on your skin — imagine where that can lead.” But IARPA pushed back on this assertion, as spokesperson Nicole de Haay told the outlet: “IARPA programs are designed and executed in accordance with, and adhere to, strict civil liberties and privacy protection protocols. Further, IARPA performs civil liberties and privacy protection compliance reviews throughout our research efforts.” Read More Swedish citizen goes on trial on charges of collecting information for Russia Seoul's spy agency says Russia has likely proposed North Korea to join three-way drills with China Biden says he is ‘disappointed’ at Xi Jinping skipping India’s G20 summit Vodafone users say they can’t call people World’s first solar-powered hybrid truck tested on public roads Apple is about to make a huge change to the iPhone that it never wanted to do

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

(Reuters) -Salesforce raised its annual revenue forecast on Wednesday and projected quarterly sales above estimates as it benefits from a

A group of UK lawmakers are calling on the government to enforce clearer and tougher rules on artificial