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With new research emerging, more questions have been raised about weight-loss injections, how they work, and the risks involved. Here are some of your questions answered. What are weight loss injections? Championed by some celebrities, including Elon Musk, weight loss injections were originally created to treat people with type 2 diabetes and other weight-related health issues. They are a type of prescription-based medical treatment that interferes with your metabolism, regulates your appetite and as a result encourages weight loss. The drugs belong to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs, which mimic the GLP-1 hormone, released in the gut after eating some food. The only FDA-approved stomach injections to help with weight management are semaglutide — sold under the brand names Ozempic, Wegovy and Rybelsus — and liraglutide — sold under Saxenda. But others are in development. Helen Knight, programme director of the Centre for Health Technology Evaluation at the National Institute for Health and Care Excellence (Nice) said: “We know that management of overweight and obesity is one of the biggest challenges our health service is facing with nearly two-thirds of adults either overweight or obese. It is a lifelong condition that needs medical intervention, has psychological and physical effects, and can affect the quality of life. “But in recent years Nice has been able to recommend a new line of pharmaceutical treatments which have shown that those people using them, alongside changes to their diet and exercise, have been able to reduce their weight.” How do they work? According to Nice’s independent appraisal committee, drugs like semaglutide should only be prescribed to patients as an alternative for weight management — alongside a reduced-calorie diet and increased physical activity in adults. They should also have a BMI of at least 35.0 kg/m2 (this is medically classified as obese), and especially, to people with a BMI of 30.0 kg/m2 to 34.9 kg/m2, have non-diabetic hyperglycaemia (blood sugar that is above normal but below those needed to diagnose diabetes) or are at high risk of other weight-related conditions such as strokes and heart attacks, due to other factors such as high blood pressure and high cholesterol. Using semaglutide as an example, a typical dose for weight loss is 2.4 milligrams, administered weekly as under-the-skin self-injections. How are they going to be rolled out? Nice formally recommended liraglutide, orlistat and semaglutide as medicines suitable to use for weight loss earlier this year. And with such drugs also available through online pharmacies by private prescription, a growing number of people have tried the jabs. If they are prescribed alongside a reduced-calorie diet, increased physical activity, and behavioural support, after a year, people taking them can lose up to 15% of their body weight, with results visible within the first month, according to the Nice clinical trials. Some weight loss injections are available on the NHS, but they are only prescribed under certain circumstances. Following an announcement of a £40 million two-year pilot on June 7, the government have said more people living with obesity will have access to the newest and most effective obesity drugs to help cut NHS waiting lists. What are the possible side effects? Europe’s drug regulator The European Medicines Agency (EMA) is investigating whether patients using some weight loss and obesity jabs are at risk of suicidal thoughts and thoughts of self-harm, which highlights some of the controversy surrounding the phenomenon. The EMA safety committee said it is looking at cases among people who use a semaglutide or liraglutide-containing medicine for weight loss – where “signals” were raised by the Icelandic Medicines Agency. “A signal is information on a new or known adverse event that is potentially caused by a medicine and that warrants further investigation,” the EMA said. “The case reports included two cases of suicidal thoughts, one following the use of Saxenda and one after Ozempic. One additional case reported thoughts of self-injury with Saxenda. “The semaglutide-containing medicine Wegovy and the liraglutide-containing medicine Saxenda are authorised for weight loss, together with diet and physical activity. “Suicidal behaviour is not currently listed as a side-effect in the EU product information of these medicines.” If you have a history of medullary thyroid cancer, gallbladder disease, or even pancreatitis, you should avoid taking weight loss injections like semaglutide. People who do take the prescription drug for weight loss sometimes experience dizziness, fatigue, and gastrointestinal issues — the most common side effects among patients — such as diarrhoea, constipation and gassiness. They are also at risk of getting headaches and stomach conditions including vomiting, bloating and nausea. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Journalist and author Yomi Adegoke on the real-life consequences of social media What is group B strep? Charity says pregnant women ‘in the dark’ Britney Spears: I worked my ass off to get my memoir written

Much of Southern Europe is sweltering under an extreme heatwave pushing temperatures well past 40C – with Italy reporting the death of a street sign painter who collapsed working in the heat. The 44-year-old worker collapsed while on the job in the northern town of Lodi on Tuesday. He was rushed to hospital but doctors were unable to revive him, according to local media. It comes as nations across Southern Europe issued warnings to both residents and tourists, as millions of holidaymakers head off for their holidays on the Mediterranean. Temperatures could spike as high as 45C to 48C in parts of Sicily and Sardinia in Italy and Cordoba and Seville before the week is out. Temperatures are also starting to tick up in Greece, where a heat wave was forecast to reach up to 44C in some parts of the country in the coming days. The heatwave was named "Cerberus" after the three-headed monster dog in Greek mythology which guards the gates of the underworld. Ruben del Campo, of Aemet, the Spanish state meteorological agency, said: “In some points of the south the temperatures will reach 44C on Wednesday. More than 100 weather stations registered temperatures of at least 35C as early as 6am on Wednesday. “In general, in Andalusia, temperatures will be above 40C. The heat will be suffocating in Cordoba and Granada and areas of the Costa del Sol”. He added: “At night temperatures will not fall below 25C in Granada, Almeria, Seville and Las Palmas in the Canary Islands.” Mr Del Campo added that from Thursday temperatures would fall in the Balearic Islands and east of the country but not in the south and west of Spain. Cristina Linares, co-director of climate, health, and urban environment at the Carlos III Institute of Health in Madrid, proposed using libraries, health centres, churches and public transport as air-conditioned places which can be used by the elderly, pregnant women and those with breathing problems as temperatures soar. In Italy, 10 cities were put on high heat alert for older people and other vulnerable populations from Bolzano in the north extending southward to Bologna, Florence and Rome. Ms Linares also warned tourists to avoid heavy drinking in the heat. “People who are not used to living in hot countries should also be warned against heavy drinking of alcohol during heat waves,” she told The Independent. But some appeared happy to disregard that advice. Jack, 13, a British schoolboy who lives in Barcelona, started selling drinks on the beach with friends. “Most people seem to want cold water and beer but I am not allowed to sell beer. We have done well. I made €7,” he said. Many homes in Spain battened down the hatches against the heat, with all windows and shutters closed during the day. In Cádiz, in southern Spain, police used air-conditioning units which were seized in raids on drug factories and installed them in public schools, which are used in summer for children’s camps. If tourists struggle with the scorching heat during the day, trying to get to sleep at night with tropical temperatures over 25C in many parts of Spain will not be easy. Spain’s state-run RTVE television ran a report advising people on the tricks to sleep properly during a heat wave. “Sleep near a window, wear little in the way of clothes, drink as much as you can and if you still cannot sleep put on the air conditioning,” the reporter told viewers. In Greece, authorities banned access to nature reserves and forests to reduce the risk of wildfires, while municipalities were opening air-conditioned areas in public buildings for people to shelter from the heat. The country's agriculture ministry also issued restrictions on the transportation and working hours of animals such as horses and donkeys offering rides in tourist areas during the heat wave. Working animals will not be allowed to work between noon and 5pm on days where temperatures are between 35C to 39C in the shade, while they will not be allowed to work at any time of the day when temperatures exceed that range. Extreme heatwaves contributed to more than 60,000 deaths in Europe in 2022, according to a report issued earlier this week. The study, conducted by the Barcelona Institute for Global Health (ISGlobal) and published in the journal Nature Medicine, estimated that 61,672 deaths were caused by extreme heat in Europe between 30 May and 4 September 2022. The highest temperature in European history was recorded in Syracuse, in Sicily in August 2021 at 48.8C. Read More G7 countries sign joint declaration in support of Ukraine at Nato summit Spain sweats out sultry nights as heat wave bakes southern Europe ‘You belong in Nato’ Rishi Sunak tells Ukrainian leader Volodymyr Zelensky Argentina turns its attention to youth divisions in search of a Messi-like player in women's soccer Red Hot Chili Peppers and Ms. Lauryn Hill will headline Global Citizen Festival to fight inequality With player stylists and Gucci collabs, MLB eyes a fresh look with younger fans

Burger King in Thailand have launched a bizarre new product - a “real cheeseburger” made with 20 slices of American cheese and no meat. The Thai operator of the US fast food chain announced that the burger was available at its outlets nationwide starting Sunday 9 July. Footage shows burger-lover Thanaporn Chatcharaporn, 26, tucking into the dish at a branch in Bangkok. “It’s very, very salty. Almost too salty to eat. The smell is also very strong. At the first bite, it gave me goosebumps, but I couldn’t finish the whole thing. I wanted to try it just to see what it was like,” she said. The glorified cheese sandwich costs around $3 - slightly cheaper than a regular meat cheeseburger. Read More Two teens found illegally smuggled in boot of car in Texas Passenger gets ‘private’ jet for £188 as no other travellers board flight Cancer survivor wears glittering eyeballs after losing left eye as baby

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Today’s Google Doodle celebrates one of India’s most famous street food snacks – the bite-sized pani puri. The dish is one of India’s most popular street foods and can incorporate many different flavours depending on the ingredients used and where in the country it is being made. The popular snack consists of a crispy, deep-fried shell that is cracked open on one side and stuffed with any combination of potatoes, chickpeas, spices or chillies dunked in flavoured water. The tiny snack is best eaten quickly in rounds, with customers dipping the shell into the water and popping it whole into their mouths before the next shell is offered. The sweet and savoury dish goes by different names in different parts of India. In capital Delhi, it is known as gol gappa, while in West Bengal, Bihar and Nepal, the snack is called phuchka. In southwestern Maharashtra, it is known by the staple pani puri, while in northern Haryana state, it is called paani patashi. In central Madhya Pradesh, the snack goes by fulki and in Uttar Pradesh, it’s called pani ke batashe or padake. In the northeastern state of Assam, locals call it the phuska, while Gujaratis call it pakodi. In parts of Odisha, Andhra Pradesh, Jharkhand and Chhattisgarh, locals call the snack Gup-chup. The process of making the humble pani puri is simple and the filling can be made according to the preference of the person eating it. The options usually consist of a potato stuffing, mashed chickpeas stuffing, boondi or tiny fried gram flour balls. A hot ragda stuffing can also be used, which is a curry or gravy preparation made from dried white peas, spices and seasonings. The server pokes a hole in the deep-drief hollow shell called the puri and fills the stuffing in it. The flavoured water, or pani in Hindi, used to dunk the filling is made either of tamarind, asafoetida, mint, garlic, lemon or jaljeera – a type of flavoured water made with chilli, cumin (jeera) and water (jal, which is another word for water) – and is served to customers one by one. One plate of pani puri usually consists of six to eight bites and costs between Rs 20-40 (£0.20-£0.40). The staple Indian snack is available in almost every north Indian restaurant locally and has only grown in popularity abroad. London’s high end Indian restaurants, like Dishoom, Roti Chai, Indian Accent and Gunpowder, also serve the dish. The snack is best enjoyed when the flavoured water is served cold. Today’s Google Doodle features a bespoke video game in which players “serve” customers’ orders for pani puri with different fillings. Google said 12 July marked the anniversary of a World Record set in 2015 for the most flavours of pani puri offered by one restaurant. It was claimed by eatery Indori Zayka in Indore, Madhya Pradesh. Read More How to shop at Borough Market in the summer ‘We call them Picky Bits’: Nigella Lawson responds to viral ‘Girl Dinner’ trend Get set for Wimbledon with these strawberry recipes Indian food influencer’s digestive mocktail recipe mocked online Ali Ahmed Aslam, chicken tikka masala ‘inventor’, dies at age 77 The tiny profit UK farmers make from the food they grow