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Sales of previously owned US homes fell to a three-month low in April, restrained by limited inventory and

Getting regular exercise such as cycling, walking, gardening, cleaning and participating in sports may decrease the risk of developing Parkinson’s disease in women, a study suggests. Women who exercised the most had a 25% lower rate of the condition when compared to those who exercised the least. The research also found that 10 years before diagnosis, levels of exercise fell at a faster rate in those with Parkinson’s than in those without, likely due to early symptoms of the disease. Experts suggest the findings support the creation of exercise programmes to help lower the risk of Parkinson’s. Our results support the creation of exercise programmes to help lower the risk of Parkinson’s disease Dr Alexis Elbaz, Inserm research centre Study author Alexis Elbaz, of the Inserm research centre in Paris, France, said: “Exercise is a low-cost way to improve health overall, so our study sought to determine if it may be linked to a lower risk of developing Parkinson’s disease, a debilitating disease that has no cure. “Our results provide evidence for planning interventions to prevent Parkinson’s disease.” Dr Elbaz added: “With our large study, not only did we find that female participants who exercise the most have a lower rate of developing Parkinson’s disease, we also showed that early symptoms of Parkinson’s disease were unlikely to explain these findings, and instead that exercise is beneficial and may help delay or prevent this disease. “Our results support the creation of exercise programmes to help lower the risk of Parkinson’s disease.” The study included 95,354 female participants, mostly teachers, with an average age of 49 who did not have Parkinson’s disease at the start of the study. The women were followed for three decades during which 1,074 of them developed Parkinson’s, and over the course of the study asked to complete up to six questionnaires. They were asked how far they walked and how many flights of stairs they climbed daily, how many hours they spent on household activities as well as how much time they spent doing moderate recreational activities such as gardening and more vigorous activities such as sports. Researchers assigned each activity a score based on the metabolic equivalent of a task (METs), a way to quantify energy expenditure. For each activity, METs were multiplied by their frequency and duration in order to get a physical activity score of METs-hours per week. For example, a more intense form of exercise like cycling was six METs, while less intense exercise such as walking and cleaning was three METs. The average physical activity level for participants was 45 METs-hours per week at the start of the study. Women in the study were divided into four equal groups of just over 24,000 people each. At the start of the study, those in the highest group had an average physical activity score of 71 METs-hours per week, while those in the lowest had an average score of 27. In the group that did the most exercise, there were 246 cases of Parkinson’s disease, compared to 286 cases in the lowest exercise group. After adjusting for factors such as place of residence, age of first period and menopausal status, and smoking, researchers found those in the highest exercise group had a 25% lower rate of developing Parkinson’s disease than those in the lowest exercise group when physical activity was assessed up to 10 years before diagnosis. They found this association remained when physical activity was assessed up to 15 or 20 years before diagnosis. The results were similar after adjusting for diet or medical conditions such as high blood pressure, diabetes and cardiovascular disease, researchers found. The findings were published in the Neurology journal. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Number of children trying vaping rises 50% in a year All of the star cars to look out for in the new Fast X film Spice Girl Geri Horner ‘so proud’ of King Charles as she gives him a hug and kiss

Despite having ambitious fitness goals, or a desire to create a change in our lives, many of us are reluctant to give up alcohol. Surely it cannot affect our fitness routines and progress that much, just to enjoy a glass of wine, or a few beers at the pub? But, as Drinkaware explains, alcohol has a negative impact on physical performance, motor skills and brain function. So, what could going sober allow us to achieve health and fitness-wise? “Since going sober two years ago, my training performance, energy levels and mental clarity have skyrocketed,” says personal trainer Josh Davies, from Aimee Victoria Long personal training. So, how does it impact your fitness? Poor sleep and hydration Alcohol has plenty of detrimental impacts on our bodies that hinder our fitness performance. “Firstly, alcohol causes dehydration. We all know the importance of being hydrated when it comes to bodily function,” says Davies. “Secondly, alcohol has a huge effect on the quality of your sleep. Alcohol prevents the body from getting into deep and REM sleep – the part of your sleep that helps with recovery and restoration. “If you’re not getting adequate amounts of this type of sleep, you won’t recover between sessions and are unable to perform when working out.”Motivation and emotions A terrible hangover or consistent fuzzy feeling is not the best if you want to get up and go when it comes to fitness, and the result-restriction caused by drinking could be holding you back. “If you’re not seeing progression in training and you’re feeling tired from the effects of alcohol, your motivation levels are likely to wane,” says Davies. Similarly, its mood-lowering effects can make you want to do anything but workout. “Whenever I used to drink too much, I used to wake up the next day and feel awful. It would leave me not being the best version of myself and stop me from pushing myself to my limits with fitness. I’d feel low, depressed and all I’d want to do is stay in bed,” says Lauren White, addiction coach and former PT. “Alcohol would always make me depressed, I would isolate and want to be alone. I was always into fitness at a young age and knew I was good at it, but when I started getting into drinking too much, I stopped looking after my body and forgot myself and my identity,” she explains. Aids with weight loss Weight loss is not, nor should it be the only goal of a fitness boost, but if it is for you, giving up drinking may help. Nick Mitchell, CEO and founder of Ultimate Performance, says: “The problem with alcohol calories is they take priority as fuel in the body over other fuel sources, as the by-product of alcohol, acetaldehyde, is toxic and converts to acetate. “This means your body won’t start burning fat again until you burn those alcohol calories off. “In fact, alcohol consumption can be one of the major reasons that you are self-sabotaging your fitness goals. “Cracking open a can of beer or two to relieve stress – although it may seem a good idea at the time – will come back to bite you. It slashes testosterone levels in men and impairs muscle growth.“Beer, in particular, is terrible for anyone seeking to lose body fat, due to its high count of calories and its estrogenic effects. This latter point can’t be underestimated – hops are estrogenic and, as such, are the prime causes of many men, not just for beer bellies, but also for man boobs,” he explains.More time and money Quitting drinking will give you more time and money to focus that energy on goals such as strength training or distance running. “You could take up new hobbies and do things that stimulate your mind and give you that serotonin release that you feel from drinking. Furthermore, you can save a bucket load of money,” says Davies. “Alcohol is expensive and when you’re intoxicated, you lose clarity and can end up spending more and more money.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 5 of this summer’s hottest swimwear trends Teenagers with obesity should be offered weight loss drug, say experts Harry and Meghan ‘not contacted by royal family’ after car chase in New York

Ugandan LGBTQ rights activist Clare Byarugaba was looking forward to showing her country off to her French partner’s

Rachel Weisz has revealed that she suffered a miscarriage in the past, while speaking about her new series Dead Ringers. The actor, 53, discussed the negative reaction to scenes of childbirth and baby loss in the show. Weisz plays twin gynaecologists in the series, which is gender-reversed remake of the 1988 horror of the same title. Speaking to Emily Maitlis and Jon Sopel of The News Agents podcast, Weisz, who is married to fellow actor Daniel Craig, said she was “surprised” by the reaction, adding: “I was just telling this story about the female experience and it didn’t seem to have been like heightened or overdramatised. “Women had miscarriages, I’ve had a miscarriage, so you suddenly see blood coming out of your body and these are just all part of a female experience of being alive.” Weisz, a mother-of-two who prefers to keep her personal life out of the public eye, did not offer further details about when her miscarriage occurred. She continued: “I think we’re not used to seeing any of those things being represented cinematically or fictionally. So maybe this is breaking some new ground, this show.” The Favourite star also gave her thoughts on US anti-abortion activists who believe in the death penalty. “Both ends of life have different rules, it is very strange,” she said. “Children have to be born but there’s going to be no free healthcare for them. There’s no free schooling for children under the age of five. “And now every day, there seems to be more and more of a chance that you might get shot by an assault rifle at school. You can take life at the end of life; the government can choose to say you deserve to die. But at the beginning of life, a woman has no choice. How do you rationalise that?” Last month, the actor addressed the graphic birthing scenes in the first episode of Dead Ringers, describing them as “beautiful”. Speaking on BBC’s Woman’s Hour, she said: “[Writer Alice Birch] and I were really interested in showing birth in the first episode. I think we felt like it was something we don’t often see. “We’re incredibly used to seeing violence and people being killed, death, blood surrounding that. We’re almost immune to that at this point. For me, it’s a beautiful moment. It’s something we’re really interested in showing.” Weisz shares 16-year-old son Henry with former partner Darren Aronofsky and four-year-old daughter Grace with husband Craig. She married Craig, 55, in 2011 in an intimate ceremony in New York with just four guests in attendance. The James Bond star also has a daughter from his previous marriage to Fiona Loudon. Read More Grandmother praised for refusing to babysit daughter’s newborn unless she’s paid $20 an hour Denise Welch recalls losing ‘sense of reality’ from post-natal depression: ‘The most terrifying thing’ Chrissy Teigen praised for thanking team of four nannies in Mother’s Day tribute Grandmother praised for refusing to babysit daughter’s newborn for free Teenagers with obesity should be offered weight loss drug, say experts Women urged to check blood pressure – here’s what you need to know

Teenagers should be offered a “transformative” anti-obesity treatment to help them lose weight, experts have said. Academics said that the weight loss injection semaglutide could help adolescents with obesity to shed pounds after a new study found an average weight loss of 40 pounds (18 kilos). Teens living with obesity were offered the semaglutide drug for more than a year in a new clinical trial. The study, published at the European Congress on Obesity in Dublin and the journal Obesity, found that 45 per cent of teens using the appetite suppressant drug were no longer classed as obese 68 weeks after starting treatment. This is compared to 12 per cent in a group who were taking “dummy” drugs – also known as placebos. Some 19.5 per cent dropped down into the “overweight” category and a quarter (25.4 per cent) were able to reduce their BMI into the “normal” weight category, the conference heard. The average reduction in body weight with semaglutide – sold under the brand name Wegovy – compared to placebo was about 40 pounds (18 kilos), researchers said. Many do very well with this medication though, and it can be life-changing for them Dr Aaron Kelly, University of Minnesota The authors of the paper conclude that “semaglutide represents an efficacious treatment option for adolescents with obesity”. But presenting the study, Dr Aaron Kelly, from the University of Minnesota Medical School in Minneapolis, USA, said that it should be taken as part of a package of measures to help teens living with the condition. He said that the earlier the treatment starts “the better” to prevent further weight gain. But he said that treatment should be taken long-term, as would be expected with other chronic conditions. Dr Kelly told reporters that there were side effects – mostly of nausea and vomiting – but these were “transient” and most dissipated over time. If you engage in treatment that’s effective, you’ll see an effect but if you take that treatment away – it’s like a rubber band, it’s going to come right back to where it started Dr Aaron Kelly “There’s a whole spectrum of outcomes when you use anti-obesity medications – some do really really well, some don’t do as well,” he said. “Many do very well with this medication though, and it can be life-changing for them. “Being a research scientist nothing brings me more pleasure than hearing the stories from the adolescents who have been struggling their entire life to manage their weight and haven’t been able to – it’s not about trying hard or not, they all try hard – this gives them a tool to help take control of their weight. “And that’s transformational for many teenagers.” He added: “I believe that health care providers should offer that as part of the comprehensive treatment approach – it’s not just one thing, it’s lifestyle therapy – which was included in this trial; it’s the use of anti-obesity medications and, for some, metabolic and bariatric surgery. “A question I get asked a lot is, ‘Is this going to solve the obesity problem? Should we just give it to everybody?’ No, it’s not going to solve the obesity problem, but it’s an important piece to the puzzle at helping to solve it especially for those who already have obesity.” Dr Kelly said that coming off the drugs would lead to weight coming back, adding: “Let’s use high blood pressure as an example, medications are commonly used and prescribed to treat high blood pressure. “And when they have prescribed, the intent of the health care provider – if (the drug is) tolerated and continues to be effective – effectively that person would stay on that medication, probably for the rest of their life. Obesity is exactly the same thing. “If you engage in treatment that’s effective, you’ll see an effect but if you take that treatment away – it’s like a rubber band, it’s going to come right back to where it started.” On when treatment should commence among teens, he added: “If obesity surfaces in childhood, it probably represents one of the most aggressive forms of obesity that we know of. “If you are a child or adolescent with obesity, you are highly likely to carry that obesity and excess adiposity into adulthood. You don’t just snap out of it. “My centre comes of the approach that the earlier the better. “And, and if medically eligible, the use of medications early is probably going to (give) the best outcomes over time because if you allow the disease to progress and the pounds to to add on over time, it gets harder and harder to draw that back. “And so conceptually, I think it makes sense to intervene early and not allow that to happen, and that probably gives the child the best shot at living a long, healthy, happy life.” Meanwhile, another study presented at the conference found that people who have shed weight may be at risk of “psychological scarring”. The paper, led by academics at the University of Liverpool, found that people who have had obesity, even if they have lost weight, could be at risk. Read More Gaining weight before 30 raises cancer risk decades later Artificial sweeteners do not help you lose weight, WHO warns How to talk to kids about weight and healthy eating Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

Hundreds of thousands of people queued online for flights to Hong Kong being given away by Cathay Pacific

A combative three-judge panel at one of the most conservative courts in the country grilled attorneys for the federal government and a drug manufacturer as anti-abortion activists continue a legal battle to overturn the government’s approval of a widely used abortion drug. On 17 May, the case against mifepristone returned to the Fifth Circuit Court of Appeals in New Orleans, where attorneys for the US Department of Justice and drug manufacturer Danco Laboratories faced skeptical Republican-appointed judges hearing oral arguments in a case that could upend abortion care for millions of Americans. Within seconds of her opening argument, Justice Department attorney Sarah Harrington was interrupted by Judge James Ho, a Donald Trump appointee, who challenged her description of the legal challenge against the drug’s approval by the US Food and Drug Administration. “I don’t think there’s ever been any court that has vacated an FDA determination that a drug is safe to be on the market,” she replied. “FDA can make that determination based on exercising its own scientific expertise, but it’s not a court’s role to come in and second-guess that expertise.” “Why not focus on the facts,” Judge Ho said, “rather than this ‘FDA can do no wrong’ theme.” The judges repeatedly interrupted Ms Harrington and appeared sympathetic to the plaintiffs: an anti-abortion group represented by influential right-wing legal group Alliance Defending Freedom, whose senior counsel Erin Morrow Halley – the wife of Republican senator Josh Hawley – baselessly asserted that medication abortion is “particularly dangerous”. Judge Jennifer Walker Elrod, who was appointed by George W Bush, also took a moment to chastise lawyers for their “unusual remarks” in filings objecting to the widely derided lower-court decision from a former right-wing activist attorney who was appointed to the federal bench by Mr Trump. Judge Elrod suggested their criticisms amounted to personal attacks and suggested that the attorney retract the statements and apologise. “Those statements reflect our view that the district court was very outside the bounds,” said Jessica Ellsworth, an attorney for Danco. “I don’t think those remarks, any of them, were intended as any personal attack.” The judges are not expected to rule immediately. But a decision from the panel judges – each with a history of support for abortion restrictions – is likely to return the case to the US Supreme Court, which has paused any action on mifepristone until the legal challenge plays out. In her arguments, Ms Hawley conflated the risk of serious complications from mifepristone – which is less than 1 per cent – with the risk that a medication abortion failed and would then require medical attention. Her arguments suggested that doctors are enduring a moral harm by providing abortion care, without evidence that doctors have been forced to do so, while also claiming that the FDA illegally approved the drug when it was approved more than 20 years ago. The judges repeatedly questioned the FDA’s approval process for mifepristone, which plaintiffs argued was done too hastily through an expedited process that is typically reserved for treating serious or life-threatening illnesses. But the FDA did not do that with mifepristone; it took years of study before the FDA’s approval. The part of that process that the agency invoked for mifepristone’s approval allowed the FDA to add safety restrictions, such as a requirement that physicians be able to diagnose ectopic pregnancies. But judges appeared to argue that because pregnancy is not an illness, mifepristone should not have been approved through that process at all, repeating plaintiffs’ false claim that the FDA called pregnancy a “life-threatening illness.” “When we celebrated Mothers’ Day, were we celebrating illness?” Judge Ho said at one point. “The arguments today demonstrated in detail that the case has no legal or scientific merit and should have been laughed out of court from the very start,” Jennifer Dalven, director of the ACLU Reproductive Freedom Project, said in a statement. “Unfortunately, the deck is stacked as the judges hearing this case are well known for their extraordinary hostility to abortion,” she added. “The whole point of the case is to prevent anyone in America, no matter where they live, from using a medication that has been safely used in this country for decades and is used in most abortions today.” Major medical groups and research from hundreds of studies over the last two decades have confirmed the overwhelming safety and efficacy of the drug, one of two drugs used in a two-drug protocol for a medication abortion, the most common form of abortion care in the US. Studies show it is as safe to use as common over-the-counter pain relievers like ibuprofen and acetaminophen, and the protocol for medication abortion is used in more than 60 other countries. The drug was first approved by the FDA in 2000 and is approved for use up to 10 weeks of pregnancy. A vast majority of abortions occur within the first nine weeks of pregnancy. From 2019 through 2020, nearly 93 per cent of all abortions were performed before the 13th week, according to the US Centers for Disease Control and Prevention. Mifepristone is also used to treat miscarriages. Roughly 10 per cent of clinically recognised pregnancies end in miscarriages, according to the American College of Obstetricians and Gynecologists. The American College of Obstetricians and Gynecologists and the American Medical Association also joined a brief in the challenge opposing arguments from anti-abortion groups. Last year, Alliance Defending Freedom filed a lawsuit in US District Court in Amarillo, Texas on behalf of a group of anti-abortion activists incorporated as the Alliance for Hippocratic Medicine, which was organised that same month with an address in Amarillo. The Alliance Defending Freedom also led the challenge at the Supreme Court that ultimately struck down Roe v Wade. In April, US District Judge Matthew Kacsmaryk – a former right-wing activist lawyer who was appointed to the federal judiciary by then-President Trump – issued a ruling to suspend the FDA’s approval of mifepristone, which was immediately challenged by abortion rights advocates, providers, major medical groups, drug manufacturers and the Biden administration. An appeal landed at the Fifth Circuit court, which has jurisdiction over the Amarillo court. A three-judge panel blocked a part of the judge’s ruling, and a subsequent ruling at the Supreme Court paused the lower-court ruling as the legal challenge continues. Read More North Carolina Republicans approve 12-week abortion ban as sweeping restrictions spread across US South Nebraska Republicans approve combined gender-affirming care ban and anti-abortion bill after epic filibuster Anti-abortion laws harm patients facing dangerous and life-threatening complications, report finds A Texas man sued his ex-wife’s friends for allegedly helping her with an abortion. Now they’re suing him Louisiana Republicans refuse rape and incest exceptions to state’s sweeping anti-abortion law What is mifepristone? The widely used pill in the abortion rights battle at the Supreme Court

Air China Ltd. has swamped an Australian flight school with a request for commercial pilots, a sudden demand

The daughter of King James VI and I was Electress Palatine of the Rhine and Queen of Bohemia, and through her grandson, the founder of a new British ruling dynasty.

A 29-year-old woman was in for a rude awakening when she asked the internet if her mother was in the wrong for refusing to babysit her newborn for free. “Am I the a**hole if my mom refused to help me take care of my baby while I go back to work?” u/erika_urrrika asked the popular Reddit forum. In her post, the new mother wrote that both she and her partner work full-time and cannot afford to have one parent stay home with their baby. The Redditor explained that their jobs don’t allow them to work from home, and they wanted to avoid spending money on childcare. In addition to being the breadwinner of the household, she is also saving money to pay off credit card debt and move to a bigger apartment. However, the grandmother refused to look after her grandchild for free, noting that she was “too old” and had “already raised her kids”. “Mind you, my mom is 64, has been a homemaker/stay-at-home-mom since 1992, and hasn’t been part of the workforce since then,” the daughter wrote. “She also added that if I really wanted this baby, then maybe I should have thought about staying home like she did to take care of it while my partner goes to work and provides for us like a ‘traditional’ family, and that if she any my dad were able to work it out, so can we.” When the Reddit user detailed her financial situation to her mother, she asked to be compensated $20 an hour for each hour she looks after her grandchild, including late fees for pickup. “So, am I the a**hole for wanting my mom, who again is at home all day long (trust me, she does not do anything besides watch TV and cook meals), to take care of my baby for free while me and my partner try to fix our finances?” she asked. In the comments, many Reddit users called the daughter “entitled” for expecting her mother to take care of her child for free. “Sorry to be blunt and rude but maybe don’t have a child if you can’t afford to take care of them,” replied one person. “And if your plan was always to go back to work you should have discussed that during the pregnancy with your mom.” “Your mother is under no obligation to babysit for you,” another user said. “Why are you having a child you don’t seem to know what to do with? And why have you not worked all this out before now?” A third person wrote: “Your mom is in no way obligated to care for YOUR BABY. It’s generous of her to be willing to do it for pay, and you have the gall to be mad she won’t do it for free? She is entitled to spend her life and free time however the hell she wants. It’s not her fault you’re in debt and decided to have a baby you can’t afford. The only thing she may have done wrong at some point along the line is raise you to be this horribly entitled.” “You chose to have a child, not your mother. Your mother isn’t a free babysitter,” another said. “She is right, she raised her children. Her babysitting on occasion would be kind and appreciated but you sound entitled thinking you are owed childcare.” One person simply commented, “You’re not the a**hole for wanting her too. But you’re the a**hole for expecting her to.” According to Sittercity, the average hourly rate of babysitters in the US in 2023 is $18.50 per hour, while the average hourly rate of nannies who “typically work on a full-time or set schedule basis” is $20 an hour. This isn’t the first time a babysitter has caused a stir on Reddit. Recently, a woman sparked a debate after revealing that she asked a family who cancelled on her babysitting services last minute to pay her half of the $840 she planned to charge them. The babysitter told Reddit’s AITA forum that she usually charges a “flat rate of $100 a night” while babysitting overnight. “Overall, the price for those three days was going to be $840,” she said. But when she received a text from the parents cancelling her babysitting services, she explained that she was “out three days pay”. In response to the last-minute cancellation, she asked the customer for $480, the “minimum [she’d] make at work in those three days”. She said the mother declined the request and said she was being “ridiculous”. While the babysitter noted that she and the family didn’t have a contract, “which in hindsight was stupid” and that “legally they don’t have to pay” her, she still felt that the right thing for the family to do was pay her. Read More Woman questions whether it was ‘selfish’ to refuse boyfriend’s request for $5,000 loan Babysitter asks family to pay half of $840 bill after they cancelled last minute People divided over whether you should switch tables in a restaurant if seated next to a crying baby Woman questions whether it was wrong to refuse boyfriend’s request for $5,000 loan Women urged to check blood pressure – here’s what you need to know Denise Welch remembers ‘losing sense of reality’ while facing post-natal depression

Marc Lasry, the billionaire co-founder of Avenue Capital Group, said he expects investments in upstart sports leagues like