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Sergio Perez’s torrid run of form continued at the Hungarian Grand Prix after he crashed out of a rain-hit opening practice. George Russell led the way in the wet conditions for Mercedes at the Hungaroring, 0.359 seconds clear of McLaren’s Oscar Piastri, with Aston Martin’s Lance Stroll third and Lando Norris fourth. Only 13 of the 20-strong field posted a competitive lap, with championship leader Max Verstappen and seven-time world champion Lewis Hamilton not risking the possibility of damage. The first one-hour running of the weekend was still dry, and barely a few minutes old, when Perez lost control of his Red Bull and ended up in the wall. The Mexican put two wheels on the grass under braking for the fifth corner, sending him into a pirouette and into the tyre barrier. Perez was unharmed in the accident but he sustained significant damage to the front of his machine. Perez is under increasing pressure at Red Bull following five consecutive qualifying sessions in which he has failed to make it into Q3. On each of those occasions, Verstappen has scored pole position in the other Red Bull. Indeed, Verstappen, who has won eight of the opening 10 rounds and six in succession, has already moved 99 points clear of his struggling team-mate. Daniel Ricciardo’s comeback at Red Bull’s junior team AlphaTauri is also likely to be playing on Perez’s mind, with the Australian admitting he is daring to dream about the possibility of a return to the grid’s all-conquering team. For now, Ricciardo has a dozen races to prove his credentials. However, the eight-time grand prix winner was among those who elected not to set a timed lap on Friday. The red flags were deployed to deal with Perez’s stricken car and then the rain arrived. The slippery conditions caught out Carlos Sainz after he lost control of his Ferrari on the exit of turn three. The Spaniard spun across the track and grazed the wall on the opposite side of the circuit before becoming stuck in the grass. A second red flag was required as marshals assisted in helping Sainz return to the pits with front-wing damage on his scarlet machine. Friday’s concluding session takes place at 5pm local time (4pm BST).

The brain’s appetite control centre is different in the brains of people who are overweight or live with obesity, a new study suggests. The researchers said their findings add further evidence to the relevance of brain structure to weight and food consumption. Current estimates suggest that more than 1.9 billion people worldwide are either overweight or obese. And, according to the Office for Health Improvement and Disparities, almost two-thirds of adults in the UK are overweight or living with obesity. This increases the risk of developing health issues like type 2 diabetes, heart disease and stroke, cancer and poorer mental health. The last two decades have given us important insights about appetite control and how it may be altered in obesity Professor Paul Fletcher, University of Cambridge A number of factors influence how much people eat and what they eat, including genetics, hormone regulation, and the environment they live in, researchers say. However, it is not entirely clear what happens to the brain to tell us that we are hungry or full. Past studies have shown that the hypothalamus – a small region of the brain about the size of an almond – plays an important role. Dr Stephanie Brown, from the Department of Psychiatry and Lucy Cavendish College, University of Cambridge, said: “Although we know the hypothalamus is important for determining how much we eat, we actually have very little direct information about this brain region in living humans. “That’s because it is very small and hard to make out on traditional MRI brain scans.” Professor Paul Fletcher, the study’s senior author, from the Department of Psychiatry and Clare College, Cambridge, said: “The last two decades have given us important insights about appetite control and how it may be altered in obesity. “Metabolic researchers at Cambridge have played a leading role in this. “Our hope is that, by taking this new approach to analysing brain scans in large datasets, we can further extend this work into humans, ultimately relating these subtle structural brain findings to changes in appetite and eating and generating a more comprehensive understanding of obesity.” The majority of evidence for the role of the hypothalamus in appetite regulation comes from animal studies, which indicate complex interacting pathways within the hypothalamus, with different cell populations acting together to tell us when we are hungry or full. To get around this researchers used an algorithm developed using machine learning to analyse brain scans taken from 1,351 young adults across a range of BMI scores. They looked for differences in the hypothalamus when comparing individuals who are underweight, healthy weight, overweight, or living with obesity. According to the findings, the overall volume of the hypothalamus was significantly larger in the overweight and obese groups of young adults. The researchers describe a significant relationship between volume of the hypothalamus and body mass index (BMI). The differences were most apparent in those sub-regions of the hypothalamus that control appetite through the release of hormones to balance hunger and fullness. While the exact significance of the finding is unclear, one explanation is that the change relates to inflammation, the researchers suggest. Eating a high-fat diet could trigger inflammation of our appetite control centre Dr Stephanie Brown, University of Cambridge Previous animal studies have shown that a high-fat diet can cause inflammation of the hypothalamus, which in turn prompts insulin resistance and obesity. In mice, just three days of a fat-rich diet is enough to cause this inflammation. Other studies have shown that this inflammation can raise the threshold at which animals are full – in other words, they have to eat more food than usual to feel full. Dr Brown added: “If what we see in mice is the case in people, then eating a high-fat diet could trigger inflammation of our appetite control centre. “Over time, this would change our ability to tell when we’ve eaten enough and to how our body processes blood sugar, leading us to put on weight.” More research is needed to confirm whether increased volume in the hypothalamus is a result of being overweight or whether people with larger hypothalami are predisposed to eat more in the first place. It is also possible that these two factors interact with each other, causing a feedback loop, the study published in Neuroimage: Clinical, and supported by the Bernard Wolfe Health Neuroscience Fund, Wellcome and the NIHR Cambridge Biomedical Research Centre, with additional funding from Alzheimer’s Research UK, suggests.

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Lewis Hamilton accused George Russell of “dangerous” driving after the Mercedes team-mates collided at 200mph in qualifying for the Spanish Grand Prix. Max Verstappen will start Sunday’s race from pole position ahead of Ferrari’s Carlos Sainz with British driver Lando Norris an impressive third for McLaren. Hamilton lines up in fourth, despite a bizarre coming together with Russell, who qualified 12th, on the main straight at Barcelona’s Circuit de Catalunya. As both Mercedes men started their hot laps in the closing moments of Q2, Hamilton moved to his left and out of Russell’s tow to assume the racing line for the first right-hander corner. But the seven-time world champion was forced to take to the grass after Russell, pre-occupied with Sainz ahead of him, closed the door. Hamilton kicked up dirt from the grass, while his right front-wing endplate flew off following contact with Russell. “George just backed off,” said Hamilton over the radio. “That is really dangerous. He pulled over to the left. I might have some damage on the car.” Although Hamilton’s time was good enough to progress to Q3, and limp back to the pits for repairs, Russell was eliminated. “You didn’t tell me there was a car behind,” said Russell. “I don’t know what the hell was going on in that session. The car was bouncing. I couldn’t get my tyres working.” Both Mercedes drivers were summoned to see the stewards to explain their version of events. Russell was let off the hook with a formal warning after he was adjudged not to have checked his mirrors. Hamilton, 38, revealed he cleared the air with Russell, 25, after he moved to draw a line under their first coming together as team-mates. “It was just a misunderstanding,” said Hamilton, who qualified fifth but moved up a place after Pierre Gasly was penalised for blocking in qualifying. “I have spoken to George. I went and shook his hand and that was it.” The Mercedes drivers were closer on track than desired after Russell aborted his previous lap. “Lewis was not aware that I was starting a quick lap,” said Russell. “I was looking ahead to get the slipstream from Sainz. “It was not something that either driver necessarily did wrong, but within the team it shouldn’t happen and the communication should have been better towards us.” Hamilton and Nico Rosberg – in the paddock on Saturday as a pundit for Sky Sports – collided on the opening lap here at the peak of their acrimonious relationship in 2016. Mercedes team principal Toto Wolff threatened Hamilton and Rosberg with a ban if they collided again. And the Austrian was asked if Saturday’s qualifying collision between his current drivers evoked memories of that race in Spain seven years ago. “No, it wasn’t shades of 2016,” he said, with a wry smile. “I wish we were in the situation of 2016 where we’re so quick. “But it shouldn’t happen. Team-mates should never collide – and even with another car, you should never collide in qualifying. “Lewis saw it as his last opportunity and didn’t think that George was on that line. It looks silly, but it wasn’t, it was just a miscommunication. “This is a team effort and we need to review our communications to avoid it in the future.” With Mercedes tripping over one another, Verstappen, who finished four tenths clear of Sainz, will be favourite to convert pole into his fifth victory from seven rounds this year. Verstappen heads Sergio Perez by 39 points in the standings, but his Red Bull team-mate starts only 11th after he fell off the road. It was a qualifying session to forget for Charles Leclerc, too, as he could manage only 19th of the 20 runners. Home favourite Fernando Alonso lines up ninth on the grid. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Max Verstappen tops rain-hit final practice for Spanish Grand Prix Lewis Hamilton toils in 12th as Max Verstappen and Red Bull dominate in Spain Fernando Alonso: Hamilton can win eighth title but Verstappen can break records

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Giorgio Armani closed Milan Fashion Week with good vibes and a front row that included Cate Blanchett, Juliette Binoche and Lily Allen. Australian actor Blanchett – a global ambassador for Armani Beauty – championed sustainable fashion by wearing an embellished black jumpsuit with a plunging neckline. The outfit comes from Armani Prive’s autumn/winter 2009 couture collection, and Blanchett is obviously a fan – she previously wore it to the Palm Springs Film Festival in January. Blanchett sat next to Chocolat actor Binoche, who kept things simple in a black leather jacket and black wide-legged trousers. Singer Lily Allen was also on the front row, sporting a sleek blunt cut bob and a pink and black ensemble. Armani’s spring-summer 2024 collection mirrored a sky’s shifting colours and light at dusk – an idea conveyed with changing colours on the back wall of the showroom in his historic, central Milan headquarters. The 89-year-old designer employed translucent, diaphanous fabrics alongside silks and satin to create lightness and movement. The palette captured the mood, moving from bronze on silvery grey to jewel blue, green and purples which bled together, and back to dusky shades of grey and silver which faded to white. “No beige,” Armani joked after the show. The collection conveyed elegance but also practicality: clothes that put the wearer at ease in any context and without prodding toward overt, revealing sexiness. Satiny trousers anchored many of the looks — jackets, transparent blouson layers, shimmering tops and off-shoulder chiffon dresses. “Vibrations, that means colours, that means movement, that means a structure that moves on the body,” Armani said. To demonstrate his vision, a model in a shimmering long dress and a diaphanous cape danced down the runway. Flat shoes finished all of the looks. “Women should not be enslaved to height or to a feline nature, being sexy at all costs,” the designer said. “There can be also a normal woman but who hopefully has a twinkle in the eye.” Armani for years has lamented a Milan fashion scene that tries too hard, focusing on novelty instead of what he sees as the essence of fashion: dressing women to express themselves. The designer said he sensed a change in this season’s Fashion Week, which ended on Sunday, with less frivolity. “Finally, I saw collections, from the photos, with a lot of normality. There is also a little research, which has to be part of this craft.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 7 gardening books you shouldn’t be without this autumn Kate Moss shares her wellness practices ahead of reaching milestone 50th birthday Naomi Campbell wears black lingerie on Dolce and Gabbana catwalk