Scientists in Israel have created a model of a human embryo from stem cells, without using sperm, eggs or a womb. A team at Israel's Weizmann Institute of Science made the model, which resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, and the work was published in the journal Nature. But the scientists involved said it would take a long time yet to create an embryo from scratch. Team leader Jacob Hanna said the team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state.They then manipulated them to make a model of an embryo, rather than an actual or synthetic one. "The question is, when does an embryo model become considered an embryo? When that happens, we know the regulations. At the moment we are really, really far off from that point," Hanna said. However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and maybe grow transplant tissues and organs. "They are not identical. There are differences from human embryos, but still, this is the first time, if you open an atlas or a textbook, you can say - yeah I can really see the similarity between them," said Hanna. "In about 1 percent of the aggregates we can see that the cells start differentiating correctly, migrating and sorting themselves into the correct structure, and the farthest we could get is day 14 in human embryo development," he said. Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50 per cent success rate. Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

The other night, I found myself with a Terrible, Horrible, No Good, Very Bad sunburn (as the fabled Alexander would put it). Now, a burn is painful enough on its own, but — as I learned — it’s especially bad at night. As I tucked myself into bed, sinking into what suddenly felt like sheets made of sandpaper, my skin screamed.

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Hot flushes and night sweats are commonly associated with the menopause – but the vast majority of menopausal women also suffer from mood and emotional problems, such as stress and anxiety. Research recently carried out by GP and menopause specialist Dr Louise Newson, founder of Balance Menopause, found 95% of nearly 6,000 perimenopausal and menopausal women had experienced a negative change in their mood and emotions during the menopause, with stress and anxiety being the most common psychological symptoms. Speaking to mark Mental Health Awareness Week (May 15-21), Newson says: “Because we often frame the menopause in terms of physical symptoms, such as hot flushes and night sweats, psychological symptoms, such as anxiety and depression, can go under the radar. “Every year I see hundreds of women struggling with menopause, and thousands more reach out on social media, looking for advice on symptoms that can impact relationships, social lives, confidence and careers.” Here, Newson, and other menopause and anxiety experts, discuss the link between the menopause and anxiety, and how to deal with it… What causes anxiety during the menopause? Low mood and anxiety can be common features of the perimenopause and menopause due to fluctuating and falling hormones, says Newson. “When oestrogen falls, levels of the mood-boosting hormone serotonin fall, too, while cortisol (the primary stress hormone) rises,” she explains. “In addition, the knock-on effects of physical symptoms, such as fatigue, hot flushes and aches and pains, can affect mood and self-esteem.” How common is menopausal anxiety? Newson’s research shows most women (95%) have some sort of mood dip during the menopausal period. Indeed, Dave Smithson, operations director at Anxiety UK, suggests anxiety is one of the key symptoms, if not the main symptom, affecting women during the perimenopause and menopause. “Often anxiety fails to receive the attention it warrants as a symptom of the menopause among the medical profession and indeed the public, which is concerning given the profound impact it can have,” he stresses. Who is likely to suffer from anxiety during the menopause?Sexual and reproductive health consultant Dr Paula Briggs, chair of the British Menopause Society, says the menopausal period has been described as a ‘window of vulnerability’, explaining: “Some women experience anxiety and low mood or depression in addition to other better-recognised menopausal symptoms. Sometimes these symptoms occur in isolation and the link with menopause may be less clear. “Mood-related changes are more likely in women who’ve had previous mental health problems, and in women experiencing surgical menopause [removal of the ovaries and or womb].” Can you get menopausal anxiety when you’ve never been anxious before? Anxiety caused by the menopause can strike women who’ve never had an anxiety problem before, Smithson points out. “Many women report new-onset anxiety, having never previously experienced anxiety at a level that it could be termed an anxiety disorder,” he says. “Others report a worsening of their pre-existing anxiety condition, as a result of the menopause.” “For women who’ve lived with anxiety for many years, when the menopause hits, they may report finding their anxiety has taken on a whole new identity, becoming more severe, intense, frequent or disabling, and consequently very challenging to manage.” What are menopausal anxiety symptoms? Although there are different types of anxiety, the symptoms tend to be the same irrespective of the underlying cause, explains Briggs. She says they can include feeling tense and nervous, being unable to relax, having difficulty concentrating, feelings of panic and dread, being unable to cope with normal daily activities, being overwhelmed, self-consciousness, and feelings of weakness and fatigue. Physical signs of anxiety include sweating, trembling, rapid heart rate and hyperventilation. “Where there’s no history of mental health problems and the symptoms and signs coincide with the menopause, they are more likely to be related to hormonal variability,” she says. “If there’s a background of anxiety and depression, then the symptoms and signs might be exacerbated by the menopause.” How is menopausal anxiety treated? Smithson says there’s still a taboo around the subject of anxiety, although he admits “great strides” towards breaking it have been made recently. “That said, access to support and treatment remain patchy, with many women left to cope alone and battle on through what can be one of the trickiest phases of their life. “Anxiety is both treatable and manageable and we would urge any women experiencing new-onset anxiety or worsening of pre-existing anxiety to seek support.” Briggs and Newson say HRT, if appropriate, is often the first treatment for menopausal anxiety, although Newson stresses: “HRT is the first-line treatment for all menopause symptoms, including mood-related symptoms. But the first piece of advice I give to any woman struggling with her mental health is to see a healthcare professional to discuss treatment options.” She suggests recording symptoms on the free balance menopause support app symptom tracker. Briggs says if necessary, antidepressant medication can improve outcomes, and talking therapies, such as CBT (cognitive behavioural therapy), are also important to help manage anxiety and depression, irrespective of the underlying trigger. “Some women, particularly those who respond partially to HRT, may need to consider adding an antidepressant, specifically one recognised to help with anxiety,” she says. However, Newson warns: “Often women are incorrectly prescribed antidepressants for menopause-related low mood and anxiety, but these mood changes are very different to clinical depression.” Can lifestyle changes help? The experts stress healthy lifestyles can really help improve anxiety symptoms, and Newson advises: “Beyond HRT, it’s so important to optimise your exercise and nutrition. A balanced diet with lots of fresh fruit and vegetables can help regulate your mood, and watch your alcohol and caffeine intake, as both can increase anxiety. “Regular exercise will lift your mood, and help you sleep, as anxiety can be a real barrier to a good night’s sleep.” She says studies suggest mindfulness can help with symptoms of anxiety and depression in menopausal women, and stresses: “Find time to focus on yourself and find some coping mechanisms you can turn to when you need them. If talking to a good friend helps with anxiety, give them a call. I find writing lots of lists helps me feel in control and calmer.” And Briggs adds: “Many women have unrealistic expectations about HRT, and it’s important to stress that lifestyle management is also an important aspect of managing the menopause, along with considering things such as cognitive behavioural therapy, hypnotherapy and mindfulness.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live How to encourage green-fingered kids Cost of sunscreen could be increasing risk of skin cancer, charity suggests Ukraine Eurovision winners Kalush Orchestra invite Princess Kate to join them on tour

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Red Bull’s Helmut Marko says Mercedes made a last-ditch attempt to sign Adrian Newey as the Silver Arrows desperately look to haul in the deficit to Formula 1’s dominant team. Newey, the lead designer behind Red Bull’s rapid RB19 car this season, last week extended his deal with the Milton Keynes outfit. Yet F1 Insider report that the 64-year-old received a phone call from a Mercedes assistant, who formerly worked at Red Bull, about opening talks regarding a potential move to Toto Wolff’s team. But Newey, who has been at Red Bull since 2006, rejected the offer and Red Bull’s special advisor Marko seemed to confirm the report while speaking at the Miami Grand Prix. “Mr. Wolff may not seem to have the full confidence in his own people to fix the problems with their car,” said Marko. Mercedes recently announced a job swap in their department, with James Alisson returning to his role of technical director and Mike Elliott taking up the position of Chief Technical Officer. Wolff labelled the W14 a “nasty piece of work” over the weekend in Miami, where George Russell and Lewis Hamilton finished fourth and sixth respectively. Mercedes, the constructors’ champions in F1 from 2014-2021, are pinning their 2023 hopes on a highly-anticipated upgrade at the next race at Imola in the hope it reduces the gap to Red Bull out in front. Red Bull, meanwhile, are expanding to become an engine manufacturer for the new set of regulations in 2026, partnering with American automotive giant Ford to form Red Bull-Ford Powertrains. Newey, who is seen by many as the main reason behind Red Bull’s supreme RB19 this season given his experience in ground-effect aerodynamics, will play an important role as the division launches in Milton Keynes. “Adrian has been such a fundamental part since almost the beginning,” Red Bull team principal Christian Horner said. “He covers a lot of a lot of areas and, to have the depth of his experience and knowledge to draw upon, and the way he works with the young guys, it’s great. “He’s just as motivated as he always [has] been. Obviously, he has a great interest in what’s going on in Powertrains, and Red Bull Advanced Technology as well. So, he covers the three pillars of the campus in Milton Keynes.” Read More Red Bull chief ‘signs new contract’ in blow to rival F1 teams ‘Nasty piece of work’: Lewis Hamilton’s Mercedes slammed by Toto Wolff Where are Mercedes and Ferrari? Frankly, you don’t want to hear the answer Max Verstappen claims Miami boos are due to his success: ‘They don’t like who wins’ George Russell takes aim at ‘distracting’ razzmatazz before Miami Grand Prix