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It was a not-so glamourous end to Paris Fashion Week, as a “widespread” outbreak of bed bugs caused panic and disgust in the French capital. Paris authorities sent out a public warning that “no-one is safe”, with the small insects making their way through the city. In recent weeks and months, there have been numerous sightings on public transport and other locations. “No one is safe. You can catch them anywhere and bring them home, and not detect them in time until they have multiplied and spread,” deputy mayor Emmanuel Grégoire, told French TV. Videos posted on social media show insects crawling over seats on the Paris Metro as well as appearing in huge numbers on cinema seats. Some users have also shared their experiences of being bitten by the critters. So, how can you help protect yourself against a bedbug infestation? Here’s everything you need to know. How do you know if you have bed bugs? To find out if you have bed bugs, it’s best to keep an eye out for two things: 1. Bites on your body – these look like little red marks that cause itchy welts. “These welts usually appear in a zigzag pattern,” the American Academy of Dermatology Association says. 2. You should always keep an eye out for signs of bedbugs, this includes odour, specks of blood on bedding, exoskeletons, tiny blackish specks and eggs. • Odour: If you notice a sweet or musty smell in your sleeping area, there might be a heavy infestation in the room, the AADA says. • Specks of blood: Look at your bedding, mattress and furniture – if you notice specks of blood anywhere, the insects might have made their way into your home. • Exoskeletons: The small insects have an outer shell that they shed and leave behind. Check for remains on your bedding, mattress and cushions. • Tiny blackish specks: The blackish specks are a sign of beg bug excrement. • Eggs: “After mating, female bed bugs lay white, oval eggs in cracks and crevices,” the AADA says on its website. These will be in the size of an apple seed, so keep your eyes peeled. How do I treat bedbug bites? The NHS says bedbug bites usually clear up on their own in a week or so but there are a few steps you can take to help you during your recovery process: • Put something cool, like a clean, damp cloth on the affected area to help with the itching and to ease off any swelling. • Be sure to keep the affected area clean to prevent any further infection. • Try your best not to scratch the affected area. You can also get steroid creams like hydrocortisone cream to ease bedbug bites. However, children under 10 and women who are pregnant should get advice from a doctor before using this cream. Another option would be to use antihistamines, these may help if the bites are very itchy and you’re unable to sleep, the NHS says. How to get rid of bed bugs – the do’s and don’ts It can be hard to get rid of the small insects on your own, so you might need to contact your local council or pest control service to get rid of the pesky creatures. Here are some steps you can take to reduce bed bugs: • Remove the affected bedding and clothing – wash on a hot wash of 60c and tumble try on a hot setting for at least 30 minutes. • You can also put the infested bedding and clothing in a plastic bag and place It in your freezer for 3 to 4 days. • It’s time to up your cleaning game – “bedbugs are found in both clean and dirty places, but regular cleaning will help you spot them early,” the NHS adds. Here’s what you should avoid doing: • Do not keep clutter around your bed, try to keep your space as clean as possible. • Do not bring second-hand furniture indoors unless you have cleaned and carefully checked it. • Do not take luggage or clothing indoors without checking it properly – especially if you have come from somewhere where you know there are bedbugs. What are the causes of bedbugs and where do they live? The wingless parasitic insects are found all around the world and may be linked to, more frequent travel, changes in pest control practices and insecticide resistance. Bedbugs can be found in: • Clothing • Luggage • Bedding • Boxes • Box springs • Mattresses • Headboards • Objects near beds According to the Mayo Clinic, they can also be found: • Under peeling pain or loose wallpaper • Under carpeting near baseboards • In upholstered furniture seams • Under light switch plates or electrical outlets Can bed bugs reach the UK? The short answer is yes… Bed bugs have a lifespan of between four to six months and are known to cling onto dirty suitcases – so it is possible that they may hitch a ride on the Eurostar which is just two hours away from London. The Independent’s Barney Davis asked David Cain, founder and MD of Bed Bugs LTD and a qualified microbiologist, whether the bugs could survive the journey. “Easily, yes, without a shadow of a doubt,” he responded. Read the latest on the bed bug infestation in Paris here. Read More Is London prepared for the mutant bedbug invasion that has swarmed Paris? That will bug you: Thousands of mosquitoes take over walls of bathroom Hotel worker shares tips on how to hunt out bed bugs How can I tell if my child has ADHD? Man inundated with criticism after judging mum on her phone Brits think investing is for the super-rich, poll finds

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The brain’s appetite control centre is different in the brains of people who are overweight or live with obesity, a new study suggests. The researchers said their findings add further evidence to the relevance of brain structure to weight and food consumption. Current estimates suggest that more than 1.9 billion people worldwide are either overweight or obese. And, according to the Office for Health Improvement and Disparities, almost two-thirds of adults in the UK are overweight or living with obesity. This increases the risk of developing health issues like type 2 diabetes, heart disease and stroke, cancer and poorer mental health. The last two decades have given us important insights about appetite control and how it may be altered in obesity Professor Paul Fletcher, University of Cambridge A number of factors influence how much people eat and what they eat, including genetics, hormone regulation, and the environment they live in, researchers say. However, it is not entirely clear what happens to the brain to tell us that we are hungry or full. Past studies have shown that the hypothalamus – a small region of the brain about the size of an almond – plays an important role. Dr Stephanie Brown, from the Department of Psychiatry and Lucy Cavendish College, University of Cambridge, said: “Although we know the hypothalamus is important for determining how much we eat, we actually have very little direct information about this brain region in living humans. “That’s because it is very small and hard to make out on traditional MRI brain scans.” Professor Paul Fletcher, the study’s senior author, from the Department of Psychiatry and Clare College, Cambridge, said: “The last two decades have given us important insights about appetite control and how it may be altered in obesity. “Metabolic researchers at Cambridge have played a leading role in this. “Our hope is that, by taking this new approach to analysing brain scans in large datasets, we can further extend this work into humans, ultimately relating these subtle structural brain findings to changes in appetite and eating and generating a more comprehensive understanding of obesity.” The majority of evidence for the role of the hypothalamus in appetite regulation comes from animal studies, which indicate complex interacting pathways within the hypothalamus, with different cell populations acting together to tell us when we are hungry or full. To get around this researchers used an algorithm developed using machine learning to analyse brain scans taken from 1,351 young adults across a range of BMI scores. They looked for differences in the hypothalamus when comparing individuals who are underweight, healthy weight, overweight, or living with obesity. According to the findings, the overall volume of the hypothalamus was significantly larger in the overweight and obese groups of young adults. The researchers describe a significant relationship between volume of the hypothalamus and body mass index (BMI). The differences were most apparent in those sub-regions of the hypothalamus that control appetite through the release of hormones to balance hunger and fullness. While the exact significance of the finding is unclear, one explanation is that the change relates to inflammation, the researchers suggest. Eating a high-fat diet could trigger inflammation of our appetite control centre Dr Stephanie Brown, University of Cambridge Previous animal studies have shown that a high-fat diet can cause inflammation of the hypothalamus, which in turn prompts insulin resistance and obesity. In mice, just three days of a fat-rich diet is enough to cause this inflammation. Other studies have shown that this inflammation can raise the threshold at which animals are full – in other words, they have to eat more food than usual to feel full. Dr Brown added: “If what we see in mice is the case in people, then eating a high-fat diet could trigger inflammation of our appetite control centre. “Over time, this would change our ability to tell when we’ve eaten enough and to how our body processes blood sugar, leading us to put on weight.” More research is needed to confirm whether increased volume in the hypothalamus is a result of being overweight or whether people with larger hypothalami are predisposed to eat more in the first place. It is also possible that these two factors interact with each other, causing a feedback loop, the study published in Neuroimage: Clinical, and supported by the Bernard Wolfe Health Neuroscience Fund, Wellcome and the NIHR Cambridge Biomedical Research Centre, with additional funding from Alzheimer’s Research UK, suggests.

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