Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

Ferrari driver Carlos Sainz topped a rain-hit practice session for the Belgian Grand Prix. With persistent rain falling at Spa-Francorchamps, not one driver completed more than eight laps. Sainz headed the timing charts, half-a-second clear of McLaren’s Oscar Piastri with team-mate Lando Norris third. Max Verstappen, who is set to serve a five-place grid penalty following a gearbox change, was among five of the 20-strong field who did not complete a timed lap. Qualifying is due to take place at 5pm local time (4pm BST), but the running is under threat given the bad weather and poor visibility generated by the spray in the Ardennes. Formula One’s governing body, the FIA, said their priority is to ensure qualifying for Sunday’s main event takes place with other sessions throughout the weekend – including Saturday’s sprint schedule – likely to be sacrificed. Heavy rain is expected to continue on Friday, and into Saturday with conditions forecast to improve on Sunday. One option is to move qualifying to Sunday morning, as the FIA did in Japan in 2019 when Typhoon Hagibis struck. If qualifying can not take place, the FIA confirmed the grid for Sunday’s main event will be set by championship order. Conditions worsened through Friday’s one-hour session with Logan Sargeant crashing out at the midway stage. The Williams rookie lost control of his car under braking for Les Combes, heading straight into the barrier. The American was unharmed in the accident but the red flags were deployed to recover his stricken machine. Alfa Romeo’s Zhou Guanyu also grazed the barrier after he ran through the gravel. The FIA’s decision whether or not to run in the wet conditions will be heightened following the death of 18-year-old Dilano Van ‘t Hoff at Spa-Francorchamps earlier this month. The Dutch teenager was killed after a crash in a rain-hit Formula Regional European Championship (FRECA) race on July 1. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live How Max Verstappen and record-breaking Red Bull compare to Formula One greats I held my breath – Lewis Hamilton enjoys ‘extraordinary’ run to pole in Budapest Max Verstappen gives hope to rivals after coming 11th in Hungarian GP practice

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Dina Lohan has revealed that her daughter Lindsay Lohan welcomed her first child “two days earlier” than her due date. Lindsay and her husband Bader Shammas confirmed via a representative on Monday (17 July) that they are now the proud parents of a “beautiful, healthy son named Luai”. In a statement, the representative added: “The family is over the moon in love.” Dina, 60, told Us Weekly that she had plans to travel to Dubai, where Lindsay and Shammas live, to be with her daughter before the birth. However, her second grandchild “decided to come early to join us sooner”, she said, adding: “We are so blessed and overjoyed and filled with so much love.” Lindsay, 37, announced that she was expecting her first child in March, less than a year after marrying Shammas in June 2022. She recently shared an inside look at her son’s beach-themed nursery with her fans on Instagram. The Falling For Christmas star posted a photograph of herself cradling her bump in front of a wall with a beach mural and a nautical-themed crib. In April, Lindsay shared photos from her baby shower with family and friends and wrote in the caption: “Good times. So grateful for all the wonderful people in my life.” She opened up about impending motherhood in an interview with Allure last month and said she “can’t wait” for the next chapter of her life. “I can’t wait to see what the feeling is and what it’s like to just be a mom,” she said. “Happy tears. That’s just who I am. Though now, it’s probably baby emotion. It’s overwhelming in a good way.” Lindsay and Shammas tied the knot last year after announcing their engagement in November 2021. In an appearance on The Tonight Show Starring Jimmy Fallon, the Parent Trap star gushed about the Arabic financier and said he was her “person”. She described married life as “so special”, adding: “It’s great. I met my person, and you never know if you’re going to find that in life. “He’s an amazing man. I love him and we’re a great team.” Read More Sorry lads, we just can’t afford any more reckless, middle-aged adventurers Cruise line apologises after passengers witness dozens of pilot whales being slaughtered Woman’s response to Tinder match asking her to go on an ice cream date sparks debate Lindsay Lohan gives birth to her first child Support with mental health issues and finances should be linked – Martin Lewis Holiday childcare costs up with fewer places available, survey finds

Welcome to Acne Files, a month-long series where we get real about whiteheads, blackheads,cysts, and every bump or blemish in between. From skin-soothing products R29 editors swear by to exclusive deals on the most breakout-friendly beauty brands, we’re kissing the concept of “bad skin” goodbye and exploring why acne goes so much further than skin deep.

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Sharon Osbourne has reminded her children of her and husband Ozzy Osbourne’s plan to die by assisted suicide, if their physical and mental health takes a severe decline. The former music manager and The Talk panellist, 71, initially discussed her end-of-life plans while promoting her 2007 memoir Survivor: My Story – The Next Chapter. In an interview at the time, Sharon said that she and Ozzy had come to the decision to visit a euthanasia facility in Switzerland, where the practice is legal. “Ozzy and I have absolutely come to the same decision,” she told the Mirror. “We believe 100 per cent in euthanasia so have drawn up plans to go to the assisted suicide flat in Switzerland if we ever have an illness that affects our brains. If Ozzy or I ever got Alzheimer’s, that’s it – we’d be off.” Sharon confirmed that their position on the matter hadn’t changed on the most recent episode of The Osbournes Podcast, hosted alongside Ozzy, 74, daughter Kelly, 38, and son Jack, 37. “Do you remember when Mum and Dad did that interview, talking about how they were gonna go and die through assisted suicide, and we were like ‘What the f*** is this?’” Kelly asked Jack. Jack replied: “They were like, ‘If we get terminally ill, we’re going to go to Switzerland and assisted suicide ourselves.’ Is that still the plan?” “Do you think that we’re gonna suffer?” Sharon asked, before laughing. To Jack’s proposal that “we [are] already all suffering”, she continued: “Yes, we all are, but I don’t want it to actually hurt, as well. “Mental suffering is enough pain without physical. So if you’ve got mental and physical, see ya.” She then clarified that if she had the chance to live longer while struggling with mental and physical issues, she’d decide against it. “What if you survived and you can’t wipe your own ass, you’re p***ing everywhere, s***ing, can’t eat,” Sharon said. “So, what’s different about your life [now]?” Kelly joked. Sharon’s strong view on having an assisted death is largely influenced by watching her father, music manager Don Arden, suffer from Alzheimer’s disease before his death in 2007. Then, in 2014, Ozzy spoke of his desire to die by medically assisted suicide in the case of any “life-threatening condition.” “If I can’t live my life the way I’m living it now – and I don’t mean financially – then that’s it...[Switzerland],” he told the Mirror. “If I can’t get up and go to the bathroom myself and I’ve got tubes up my ass and an enema in my throat, then I’ve said to Sharon, ‘Just turn the machine off.’ If I had a stroke and was paralyzed, I don’t want to be here. I’ve made a will and it’s all going to Sharon if I die before her, so ultimately it will all go to the kids.” If you are experiencing feelings of distress, or are struggling to cope, you can speak to the Samaritans, in confidence, on 116 123 (UK and ROI), email jo@samaritans.org, or visit the Samaritans website to find details of your nearest branch. If you are based in the USA, and you or someone you know needs mental health assistance right now, call the National Suicide Prevention Helpline on 1-800-273-TALK (8255). This is a free, confidential crisis hotline that is available to everyone 24 hours a day, seven days a week. If you are in another country, you can go to www.befrienders.org to find a helpline near you. Read More Inside the secret network of women naming and shaming their bad exes How to really tell if you’re Posh (or not) The rise of ‘Ozempic face’ and why it’s here to stay Billy Connolly says reports of his ‘demise have been greatly exaggerated’ How to get rid of bedbugs: Signs and symptoms amid threat of UK invasion Dawn O’Porter: ‘I fantasise about the other side of menopause’