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Working out for just about 20-25 minutes daily may be enough to cut a heightened risk of death due to a highly sedentary lifestyle, a new study finds. Adults in developed countries spend about 9-10 hours on average every day sitting down mostly while working, with the highly sedentary lifestyle linked to a heightened risk of death. The research, published in the British Journal of Sports Medicine, found just about 25 minutes of daily moderate to vigorous physical activity (MVPA) eliminates the risk of high sedentary time. Individual data from four groups of people, who were fitted with activity trackers, was pooled for the latest study by scientists, including those from The Arctic University of Norway. Researchers sought to find out whether physical activity might modify the association between sedentary time and death, and what amount of physical activity and sitting time may influence the risk. The analysis included data from nearly 12,000 people aged at least 50, who had a minimum of 4 days of 10 daily hours of activity tracker records. The participants had been monitored for at least two years, and had provided details of potentially influential factors, including their sex, educational level, weight, height, smoking history, alcohol intake and whether they had current and/or previous cardiovascular disease, cancer and/or diabetes. About 5,950 people spent fewer than 10.5 hours sitting down every day, while 6,042 clocked up 10.5 or more sedentary hours. Data from death registries found that during an average period of five years, 805 (7 per cent) people died, 357 (6 per cent) of whom spent under 10.5 hours sitting down every day and 448 of whom clocked up 10.5 hours or more. Being sedentary for more than 12 hours a day was found to be associated with a 38 per cent heightened risk of death compared with a daily tally of eight hours. But this was only among those registering fewer than 22 daily minutes of moderate to vigorous physical activity, scientists said. The study found over 22 daily minutes of moderate to vigorous physical activity was linked with a lower risk of death. Higher daily tallies of physical activity were found to be linked to an even lower risk irrespective of the amount of time spent seated every day. For instance, an extra 10 minutes a day of exercise was linked to a 15 per cent lower risk of death in those spending fewer than 10.5 sedentary hours. This extended duration of workouts was associated with a 35 per cent lower risk among those spending more than 10.5 sedentary hours every day. Citing the study’s main limitation, scientists said the research was observational and can’t establish cause and effect. The study could also not account for other potentially influential factors like diet, mobility issues and general health. However, scientists said small amounts of MVPA “may be an effective strategy to ameliorate the mortality risk from high sedentary time”. Read More Study reveals why millions of women wake up at 3.29am Sports culture is ‘intimidating’ and putting people off working out, study finds Running could be just as effective at treating depression as medication, scientists find This Chinese martial art may slow down Parkinson’s disease The best ways to work-out in 22 minutes – as study finds this is magic number for offsetting ‘negative impact of sitting’ Mick Jagger, father of eight, explains why parenting is ‘not like riding a bike’

The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

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