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With new research emerging, more questions have been raised about weight-loss injections, how they work, and the risks involved. Here are some of your questions answered. What are weight loss injections? Championed by some celebrities, including Elon Musk, weight loss injections were originally created to treat people with type 2 diabetes and other weight-related health issues. They are a type of prescription-based medical treatment that interferes with your metabolism, regulates your appetite and as a result encourages weight loss. The drugs belong to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs, which mimic the GLP-1 hormone, released in the gut after eating some food. The only FDA-approved stomach injections to help with weight management are semaglutide — sold under the brand names Ozempic, Wegovy and Rybelsus — and liraglutide — sold under Saxenda. But others are in development. Helen Knight, programme director of the Centre for Health Technology Evaluation at the National Institute for Health and Care Excellence (Nice) said: “We know that management of overweight and obesity is one of the biggest challenges our health service is facing with nearly two-thirds of adults either overweight or obese. It is a lifelong condition that needs medical intervention, has psychological and physical effects, and can affect the quality of life. “But in recent years Nice has been able to recommend a new line of pharmaceutical treatments which have shown that those people using them, alongside changes to their diet and exercise, have been able to reduce their weight.” How do they work? According to Nice’s independent appraisal committee, drugs like semaglutide should only be prescribed to patients as an alternative for weight management — alongside a reduced-calorie diet and increased physical activity in adults. They should also have a BMI of at least 35.0 kg/m2 (this is medically classified as obese), and especially, to people with a BMI of 30.0 kg/m2 to 34.9 kg/m2, have non-diabetic hyperglycaemia (blood sugar that is above normal but below those needed to diagnose diabetes) or are at high risk of other weight-related conditions such as strokes and heart attacks, due to other factors such as high blood pressure and high cholesterol. Using semaglutide as an example, a typical dose for weight loss is 2.4 milligrams, administered weekly as under-the-skin self-injections. How are they going to be rolled out? Nice formally recommended liraglutide, orlistat and semaglutide as medicines suitable to use for weight loss earlier this year. And with such drugs also available through online pharmacies by private prescription, a growing number of people have tried the jabs. If they are prescribed alongside a reduced-calorie diet, increased physical activity, and behavioural support, after a year, people taking them can lose up to 15% of their body weight, with results visible within the first month, according to the Nice clinical trials. Some weight loss injections are available on the NHS, but they are only prescribed under certain circumstances. Following an announcement of a £40 million two-year pilot on June 7, the government have said more people living with obesity will have access to the newest and most effective obesity drugs to help cut NHS waiting lists. What are the possible side effects? Europe’s drug regulator The European Medicines Agency (EMA) is investigating whether patients using some weight loss and obesity jabs are at risk of suicidal thoughts and thoughts of self-harm, which highlights some of the controversy surrounding the phenomenon. The EMA safety committee said it is looking at cases among people who use a semaglutide or liraglutide-containing medicine for weight loss – where “signals” were raised by the Icelandic Medicines Agency. “A signal is information on a new or known adverse event that is potentially caused by a medicine and that warrants further investigation,” the EMA said. “The case reports included two cases of suicidal thoughts, one following the use of Saxenda and one after Ozempic. One additional case reported thoughts of self-injury with Saxenda. “The semaglutide-containing medicine Wegovy and the liraglutide-containing medicine Saxenda are authorised for weight loss, together with diet and physical activity. “Suicidal behaviour is not currently listed as a side-effect in the EU product information of these medicines.” If you have a history of medullary thyroid cancer, gallbladder disease, or even pancreatitis, you should avoid taking weight loss injections like semaglutide. People who do take the prescription drug for weight loss sometimes experience dizziness, fatigue, and gastrointestinal issues — the most common side effects among patients — such as diarrhoea, constipation and gassiness. They are also at risk of getting headaches and stomach conditions including vomiting, bloating and nausea. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Journalist and author Yomi Adegoke on the real-life consequences of social media What is group B strep? Charity says pregnant women ‘in the dark’ Britney Spears: I worked my ass off to get my memoir written

“Now it’s time to cross over to our F1 Juniors,” said Sky’s lead presenter Simon Lazenby, in a feel which became familiar throughout the Hungarian Grand Prix weekend. Often the broadcaster striving for new avenues, never afraid of the status quo, Sky Sports took their television trials to a different avenue this weekend with the first-ever Formula 1 broadcast for children. An admirable experiment, it gave three teenagers a few days to savour as they started their summer holidays in Budapest alongside broadcasters Radzi Chinyanganya and Harry Benjamin. For Braydon, Scarlett and Zak – the latter a go-karter at junior level, the former duo presenters on Sky’s BAFTA-winning kids show FYI – it presented opportunities of a lifetime with interviews, quizzes and predictions with the best drivers and pundits in the paddock. And it provided some indisputably heartwarming moments. Like the segment where Zak met Lewis Hamilton and spoke to his hero about how inspiring the Mercedes star has been to black kids around the world, before then sitting in his Mercedes car. Or Scarlett and Braydon quizzing the “terrible trio” of George Russell, Lando Norris and Alex Albon about what ice cream they’d describe themselves as. “Vanilla”, Norris quipped, pointing at Russell. There’s something about the involvement of adolescents in a press environment which can bring some much-needed lightheartedness to what can sometimes be a sterile process for all involved. For example, who can forget the young boy, in awe of his sporting icon, who asked Roger Federer at the US Open in 2017: “Switzerland is really cool, right? There isn’t too much livestock. So why do they call you the GOAT [greatest of all time]?” Yet, away from one-on-ones with drivers, the core aspect to the alternative broadcast was the informal race coverage, live on free-to-air Sky Showcase, which presented an F1 race in an entirely different format. There were bright, 3D-augmented graphics throughout, with a colour-coordinated leaderboard which, frankly, seemed clearer than the usual feed at times. Explainers popped up at various points, defining key F1-focused terms for younger viewers. The use of avatars for each driver was a cute touch, though obviously best kept for this experiment. Overall, it provided something completely unique and distinctive for a 70-lap race which provided a common routine in the obligatory Max Verstappen victory. Sure, nobody was asking for an F1-kids broadcast. And inevitably, naysayers online will have been quick to roll their eyes at the initiative. It was notable that both Sky F1 and Benjamin turned off replies to their tweets involving F1 Juniors over the weekend. Less an indication of the general reaction to the initiative and more a sign of the times – and the highly-charged, often-abusive nature of social media. But that is not the point. F1 has for a while been a step ahead of other sports in the intuitiveness and creativity of its product, to the stage now where it is in the midst of a period of unprecedented worldwide popularity. The most obvious is the fly-on-the-wall nature of Drive to Survive on Netflix, a format only now being followed by the professional tennis and golf tours in search of extra eyeballs. It is a fine balancing act, though. During practice and the qualifying show, there were regular interspersions on the main feed to the Juniors, a process which may well have irritated petrolheads and fans of a sterner generation. While Sky like to push boundaries, their executives will be all too aware of trying to avoid alienating their core viewership. The one-off nature of F1 Juniors, at least this season, means this is unlikely to materialise. And there were moments of awkwardness. Like cutting to Christian Horner on the pit wall, seemingly in a baffled daze, who bluntly said: “Can we come back and do this in another 10 laps or so?” Like a selfie in the commentary booth with Danica Patrick, who had earlier stated the nature of sport “is masculine and aggressive” as she spoke about the lack of female racing drivers. There were obviously a few mistakes here and there – and it wasn’t completely crisp and clear-cut. But then it wasn’t meant to be. And, frankly, nor is David Croft and Martin Brundle’s expert commentary always error-free. In a sport as technical and fast-paced as F1, perfection is near-on impossible. Of course, unless you’re Verstappen at the moment. But the underlying takeaway is this: as a child, all you want to be is treated as a grown-up. The best way of learning about the intricacies of a sport like Formula 1 is to immerse yourself in the usual feed on a regular basis, creating a curiosity gap to discover more. As a one-off, F1 Juniors was worthwhile and undoubtedly a commendable initiative. For intrigued parents, showing their children an F1 race for the first time, who knows how many may have flicked on the coverage? Who knows how many might now flick on an F1 race in the future on a Sunday afternoon? Something different is not to be something dismissed. Article originally published on 24 July 2023 Read More Lewis Hamilton makes damning statement about his level after Hungarian GP Daniel Ricciardo is back - and this time he wants to go out on top F1 Singapore Grand Prix LIVE: Qualifying updates and times at Marina Bay FIA take action against Helmut Marko after comments about Sergio Perez Zhou Guanyu interview: ‘There is a lot of pressure – only winners stay in F1’

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