The U.S. Food and Drug Administration declined to approve a nasal spray to treat severe allergic reactions, calling for more research on what would have been the first alternative to injections using devices such as an EpiPen

Max Verstappen has hit back at criticism of his dominance and set the target of remaining unbeaten for the final nine races of the season. The all-conquering Dutchman will become the first driver in history to win 10 consecutive races if he takes the chequered flag at the Italian Grand Prix on Sunday. Verstappen has been in imperious form this year, winning 11 of the 13 rounds staged as he closes in on a hat-trick of World Championships. With a lead of 183 points heading into this weekend’s race in Monza there is a chance he could even close out the title with six rounds still remaining at the Japanese Grand Prix on September 24. However, Verstappen’s emphatic streak has led to suggestions that the sport has become boring. But responding to the accusations in an interview with the PA news agency, Verstappen, 25, said: “They cannot appreciate dominance or just people executing their jobs. “It is nothing really new in Formula One, and I cannot do much with those kind of comments. Does it bother me? No. It would probably be worse if they were talking about other stuff. I am enjoying what I am doing and I hope I can do it for a while. “I don’t want it to stop. We have another good opportunity this weekend. I believe I can win every single race.” Verstappen’s victory on his home track in Zandvoort – which drew him level with Sebastian Vettel’s record of nine straight wins – was among the very best of the 46 of his career so far. At one stage, he was lapping four seconds faster than Sergio Perez in the other Red Bull, and two seconds quicker than anybody else. His virtuoso display in the inclement conditions prompted double world champion Fernando Alonso to say Verstappen’s achievements are being underestimated. “It is not about getting the recognition because I know how hard it is to do,” said Verstappen. “If it was very easy, more drivers would have won nine in a row, and more teams would have done it, and that is not the case. “It hasn’t been straightforward either. In Zandvoort especially, a lot of things could have gone wrong, and in the end we still handled that really well. “I never thought I would get to nine. I remember watching Seb do it, and I was like, ‘Jesus Christ, that is extremely difficult’, and now I am here and it is amazing.” Verstappen will share the grid with long-time rival Lewis Hamilton for at least another two seasons after the British driver signed a new £50million-a-year deal to remain with Mercedes. The contract extension will take Hamilton beyond his 40th birthday, and provides the possibility of a championship rematch with Verstappen if Mercedes can somehow close the gap to Red Bull. Hamilton, who was denied an eighth world title after race director Michael Masi failed to follow the correct rules in Abu Dhabi in 2021, alluded to “unfinished business” after signing his latest deal. Twenty months on from F1’s most contentious race, does Verstappen – who, on new tyres, had to pass Hamilton on the final lap to take the title – feel his maiden championship triumph was tainted? “It was not like it was given to me,” he said. “I still had to do it. “People always have short memories and they can forget a lot of stuff very quickly. “It was a great year, and we had a lot of great battles with two teams going at it and that was amazing for Formula One. “But you will always have a winner, and you will always have a loser. That is how this sport works, and I was also ready to lose. “It was a 50-50 chance and it fell my way. But in the future I could be in a situation where it doesn’t fall my way and that is how life goes. “I don’t really care a lot about other people’s opinions. I only care about people that are very close to me so whatever people say or write, I am like ‘whatever’. “I grew up my whole life wanting to be a Formula One driver and I will do everything it takes to try and be successful at it. “I make my choices and my decisions and that is why I am very relaxed about these things. I go home, I switch off from Formula One, and I am happy with my career. And when I come back to the race weekends I do my thing, and that is it.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live How Max Verstappen equalled Sebastien Vettel’s record for consecutive race wins Max Verstappen reveals Sebastian Vettel prediction as he closes on GP record run Max Verstappen is one of the best drivers in F1 history – Lando Norris

Fans of Dame Helen Mirren were left stunned after the actor debuted her bright blue hair at the Cannes Film Festival. The Oscar-winning actress, 77, arrived on the red carpet on the opening day of the 76th annual event on Tuesday (16 May). Mirren wore her hair in a messy updo highlighted with varying shades of blue and turquoise. She paired the look with a floor-length periwinkle gown, which featured folds around the waistline and an elaborate bustle in the back. The actor also carried a black fan with #WorthIt written on it in a nod to her partnership with L’Oreal Paris. Fans have been praising Mirren for experimenting with her hairstyle. “When I go grey I too shall match my hair to my outfit,” wrote one person on Twitter. Canadian fashion expert Lisa Tant wrote: “Helen Mirren turns the blue haired old lady stereotype on its head.” Mirren’s vibrant hair colour was not her first at the international film festival. In 2019 she attended with a shorter cut that was swooped back and dyed pink. She previously told US outlet People magazine that she had been inspired to make the changes after watching reality TV. “I was watching an episode of America’s Next Top Model and there was this little English girl on it,” she said. “She had bright pink hair and she looked so great.” With additional reporting from PA. Read More Vanessa Feltz blasts Ann Widdecombe over 40p cheese sandwich remark Denise Welch recalls losing ‘sense of reality’ from post-natal depression: ‘The most terrifying thing’ Fans aghast after Kanye West’s ‘wife’ Bianca Censori wears cross-shaped body tape Helen Mirren debuts blue hair look on opening day of Cannes Fans aghast after Kanye West’s ‘wife’ Bianca Censori wears cross-shaped body tape Italian designer launches scathing attack on Shein over ‘stolen ideas’

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Ever wondered what those shoulder buttons on jackets are for? Wonder no more. A tweet attempting to explain their purpose has resurfaced and gone viral once again, educating the masses - maybe... The tweeter reckoned they are put on jackets so you can "hold your bag in place". Sign up to our free Indy100 weekly newsletter "Taken me 18 years to find out that the weird shoulder buttons on jackets is to hold your bag in place so it doesn’t fall off who knew," the 2018 tweet said. It has recently been screenshotted and shared by another Twitter account: Responding to the tweet, one commenter wrote "mind blown" and another said "wow". But the tweet also sparked a debate. One explained that the buttons are actually called "epaulets" which are ornamental shoulder decorations to reveal a rank in the armed forces. "What a load of nonsense,they are epaulettes," another said. "Designed to display rank on a jacket, shirt or jumper. Hold a bag in place..pish." "Are you kidding me," another said. So now you know. Don't believe everything you see on Twitter... Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.