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The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

Angelina Jolie has admitted that she’s still trying to figure out what her style is, as she opened up about wanting to look “soft” after being “hurt” in the past. The actor, 48, spoke candidly about her fashion sense during a recent interview with Vogue to discuss her new brand, Atelier Jolie. She began by describing how she believes people perceive her based on the clothes she wears. “Sometimes the way you dress says: ‘Don’t mess with me - I’ve got my armour on,’” she said. “But I want a woman to feel safe enough that she can be soft.” The Maleficent star revealed that when she was faced with a difficult time in her life, she was ultimately encouraged to choose clothes that made her look “soft”. “After I went through something where I was hurt, I had a therapist ask if I would try wearing a flowing garment,” she said. “Sounds silly, but I assumed that pants and boots projected a ‘tougher’ look, a stronger me. But was I strong enough to be soft?” While Jolie confessed that she didn’t feel too strong at time, she acknowledged that she’s still figuring out what her style is - despite being hurt in the past. “I felt vulnerable. Now I wonder if I don’t know what my style is because I’m still understanding who I am at 48. I guess I’m in transition as a person,” she added. The Salt star seemingly alluded to some of the personal challenges she faced over the years, including her split from ex-husband Brad Pitt in 2016. “I feel a bit down these days. I don’t feel like I’ve been myself for a decade, in a way, which I don’t want to get into,” she said. Jolie added that she’s in a place in her film career where she’s “only taking jobs that didn’t require long shoots” after spending the last seven years doing “a lot of healing”. She also noted that while she’s “still finding [her] footing”, her work with her fashion brand has offered her a new perspective. “I think part of this has also been therapeutic for me - to work in a creative space with people you trust and to rediscover yourself,” the actor explained. “I’m hoping to change many aspects of my life. And this is the forward-facing one.” In May, Jolie took to Instagram to announce the launch of Atelier Jolie, which she described as “a collective where everyone can create”. “Atelier Jolie is a place for creative people to collaborate with a skilled and diverse family of expert tailors, pattern makers and artisans from around the world,” she wrote in the caption. “It stems from my appreciation and deep respect for the many tailors and makers I’ve worked with over the years, a desire to make use of the high-quality vintage material and deadstock fabric already available, and also to be part of a movement to cultivate more self-expression.” During her interview with Vogue, the Mr & Mrs Smith star spoke candidly about her new career in the fashion industry, noting that her brand is “not really about fashion”. “I don’t want to be a big fashion designer,” Jolie said. “I want to build a house for other people to become that.” Read More Angelina Jolie says her children ‘saved’ her as she opens up about ‘healing’ after Brad Pitt divorce Salma Hayek reveals what she loves most about her friendship with Angelina Jolie Brad Pitt and Angelina Jolie ‘set to try and resolve’ longrunning vineyard dispute Angelina Jolie says her children ‘saved’ her as she opens up about Brad Pitt divorce Salma Hayek reveals what she loves most about her friendship with Angelina Jolie Sarah Jessica Parker’s custom 2014 Met Gala dress goes up for auction

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The social media platform formerly known as Twitter has lost a lot of its appeal.