SAN JOSE, Calif.--(BUSINESS WIRE)--May 9, 2023--

A recent investigation has found that some Ozempic and Wegovy patients suffered from severe gastroparesis, also known as stomach paralysis, after taking the medications. In a report from CNN published on 25 July, two patients reported that their “stomachs are paralysed” after taking type 2 diabetes drug Ozempic – a semaglutide injection known for its weight loss side effects. “I wish I never touched it. I wish I’d never heard of it in my life,” Joanie Knight, a 37-year-old from Louisiana, told CNN. “This medicine made my life hell. So much hell. It has cost me money. It cost me a lot of stress; it cost me days and nights and trips with my family. It’s cost me a lot, and it’s not worth it. The price is too high.” Emily Wright, a 38-year-old teacher from Toronto, said she vomits so frequently that she had to take a leave of absence from her job. “I’ve almost been off Ozempic for a year, but I’m still not back to my normal,” she said. According to CNN, both women have been diagnosed with severe gastroparesis, a disorder that slows or stops the movement of food from the stomach to the small intestine, per the Mayo Clinic. Wright has also been diagnosed with cyclic vomiting syndrome, which causes her to throw up multiple times a day. Meanwhile, one Wegovy user claimed she began experiencing stomach problems after her doctor prescribed her the weight loss drug – which works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), regulating blood sugar levels and slowing down the rate at which food leaves the stomach to create the feeling of fullness. However, the medication caused her to vomit so much that she became dehydrated and needed to visit urgent care. Brenda Allen, from Texas, has since been managing her nausea and vomiting with a medication called Zofran and prescription probiotics. Now, the US Food and Drug Administration has said they’ve received reports of stomach paralysis among patients taking the medications. “The FDA has received reports of gastroparesis with semaglutide and liraglutide, some of which documented the adverse event as not recovered after discontinuation of the respective product at the time of the report,” the agency said in a statement to CNN. However, officials clarified that they were unable to determine whether taking Ozempic or Wegovy was the cause of stomach paralysis, or if it was caused by a different issue. “Gastroparesis can be a complication of diabetes that is related to long-standing or poorly controlled disease, further complicating the ability to determine what role the drugs played in the reported events,” they said. As for whether patients should be warned about taking the drugs, the FDA maintained that taking the medications, such as for treating diabetes or weight management, may still “outweigh the risks in some patients with gastroparesis or delayed gastric emptying”. In response to reports of stomach paralysis, Novo Nordisk – the manufacturer behind Ozempic and Wegovy – noted that these drugs have been extensively studied in the real world and in clinical trials. “Gastrointestinal (GI) events are well-known side effects of the GLP-1 class,” the company told CNN. “For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.” Last week, the American Society of Anesthesiologists also issued a warning that those who take GLP-1 agonists should avoid the medications a week before surgery because they may increase “risk of regurgitation and aspiration of food” while under anesthesia and deep sedation. Ozempic, a once-weekly injection used for the treatment of type 2 diabetes, has skyrocketed in use after people were reportedly prescribed the FDA-approved diabetes medication as an “off-label” weight loss drug. However, because of its increasing popularity, it has led to national shortages of the diabetes treatment - leaving those who actually need Ozempic without it. Meanwhile, Wegovy and Mounjaro are popular once-weekly semaglutide injections specifically approved for the treatment of obesity and weight loss. There are many side effects of taking medications like Ozempic, Wegovy, and Mounjaro. According to the FDA, the most common side effects of taking Wegovy are nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, and digestive disorders. The FDA has also warned about more serious complications that can occur from use of Wegovy or Mounjaro, such as the “potential risk of thyroid C-cell tumours,” pancreatitis, gallbladder problems, acute kidney injury, increased heart rate, and suicidal behaviour or thinking. Taking Ozempic can also lead to possible thyroid tumours, including cancer, pancreatitis, changes in vision, and kidney and gallbladder problems. The Independent has contacted Novo Nordisk and the FDA for comment. Read More Clinics told to stop prescribing medicines as weight loss drug hits diabetes supply Influencer addresses ‘dangers’ of complimenting people’s bodies after weight loss comments Ozempic under EU investigation over reports of suicidal thoughts Mindy Kaling shuts down weight loss question as ‘people take it so personally’ What are weight loss injections and what’s the controversy? Raven Symone says people shouldn’t use Ozempic for ‘glamazon purposes’

A Texas judge issued an order late Friday temporarily barring the state from enforcing its ban on abortion after about six weeks of pregnancy in cases where a patient's life or health could be endangered by an "emergent medical condition."

Whether you’re an advocate of a 10-step skincare routine or more into “skinimalism,” chances are you’ve tried vitamin C before. Otherwise known as ascorbic acid, the skincare ingredient has multiple proven benefits: As an antioxidant, it protects the skin against environmental aggressors such as pollution; it also minimizes hyperpigmentation by controlling excess melanin (our skin’s natural pigment), and boosts collagen, which depletes as we age.

A London-based chef has apologised for what his peers branded a “rude” response towards criticism, after he faced backlash online for revealing the line-up of his kitchen team at his Notting Hill restaurant. Thomas Straker, who opened his namesake restaurant Straker’s in 2022, recently shared a photograph of his “chef team” comprising eight people, including himself. All eight members of the team pictured were white and male, prompting complaints from social media users who believed it did not reflect the diversity of London. Some comments claimed Straker’s team showed how the food industry was a “white boy’s club”, while others urged the restaurateur to provide chefs from minority groups a “safe place to grow as chefs”. Straker, who found fame by sharing his recipes and cooking videos on TikTok, responded to the negative backlash by commenting: “Honestly, people need to calm down. Firstly, there is a shortage of chefs/hospitality workers. Secondly, if you feel so passionately, please go and gather CVs of any chefs you think we’re missing in the team. Solutions not problems. Thank you.” However, his response has also been criticised as “rude”, with a number of chefs and other figures in the food industry weighing in on the online storm. He has since shared an apology via his Instagram Story. “On Friday night, I put up a post of my chef team and many rightly pointed out the lack of diversity in it. I am very sorry for my initial response, where some queried whether I take this issue seriously,” he said. “I am absolutely committed to ensuring diversity in my restaurants, unfortunately we aren’t achieving this in my kitchens currently and this is an area I know I need to improve on, making sure it is seen as a welcoming and approachable environment for all. Tom x.” Becky Paskin, a drinks expert who appears regularly on ITV’S Love Your Weekend, wrote on Straker’s original post: “Too often we say, ‘We only recruit on the basis of the best people for the job’ without any consideration the role bias plays in the selection process. “It’s been proven time and again that diverse teams are more creative, productive and successful. If every member looks the same and has the same background, you’ll find they’ll all think the same as well. Forming diverse teams is not only the right thing to do, it makes business sense too.” US chef Kenji Lopez-Alt, who is known for his book The Food Lab: Better Home Cooking Through Science, added: “Get off the social media for a week or so. Do some reflection. Talk to people who care about you and who you trust. Be better.” However, some people have defended Straker’s choice to hire who he wants in his team, and pointed out the staff shortage affecting the entire restaurant industry. Henry Tilley, restaurant manager at Native in London, wrote: “The industry is on its knees right now. There [aren’t] enough chefs or even [front-of-house staff] to go around as it is. We would love some applications for chef positions in our restaurants from female or non-binary individuals. The reality of the matter is we never get the applications so can’t be as representative as we’d like.” But Ben Mulock, executive chef of Balans in Soho, says the onus is on senior chefs to “solve the problem” of lack of diversity, instead of “asking others to solve it for us”. He told The Independent: “I am a white male executive chef, so it is my responsibility to push for an inclusive workforce, be that sex, age or ethnicity. They are not mutually exclusive – they are all important. “No, it’s not easy and at the moment, it almost seems impossible to recruit, but if we don’t try, we don’t move it forward. We always need to do better for this industry, and if we can’t do it in London, where can we?” While Straker’s post was not intended to stir controversy, the lack of diversity in his team has “shone a light on the broader challenges we face in kitchens these days”, Hannah Norris of Nourish PR said. “This is a classic case of an ill thought-out post,” she told The Independent. “Thomas Straker has issued what he believed was a photo of a group of confident, strong-looking chefs ready for service but didn’t think about the optics of the image and what it represented. “Whilst it was well-meaning I believe, a picture doesn’t lie. For whatever reason, he currently has no women or people of colour in his kitchen, so it all looks a bit ‘pale, male and stale’. Perhaps the reaction to this image will make Thomas think again a bit more carefully about who he wants to employ in the future.” The Independent has contacted Straker for comment. 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McLaren boss Zak Brown has called on Formula One’s governing body to ensure the track-limits fiasco which overshadowed the Austrian Grand Prix never happens again. Drivers were penalised throughout the weekend at the Red Bull Ring in Spielberg for crossing the white lines – with the final classification for Sunday’s race only settled five hours after the chequered flag. Eight of the 20-strong grid were dealt post-race sanctions by the FIA, with Lewis Hamilton demoted from seventh to eighth. Ferrari’s Carlos Sainz slipped two places to sixth, while Frenchman Esteban Ocon was handed an extraordinary half-a-minute’s worth of combined penalties for track-limit infringements. Earlier in the weekend, world champion Max Verstappen accused race director Niels Wittich of making the grid’s stars look like “amateurs”. In all, more than 100 laps were deleted during Sunday’s race. “It definitely wasn’t ideal what happened, and that’s stating the obvious,” said Brown. “Where we need to do a better job is that we knew this was going to be a problem on Friday and yet we just kind of watched it happen. “We need to make sure it never happens again, and that we do a proper debrief and understand how we could have prevented it in the first place or handled it differently.” McLaren driver Lando Norris benefited from Sainz’s post-race penalty to be promoted to fourth to take his best result of a difficult season for the British team. Brown, speaking at the reveal of a one-off livery for McLaren’s home race at Silverstone this weekend, continued: “I’ll take my hat off to the FIA for addressing the issue and I think it would have been easy to say, ‘this is going to cause a lot of noise, let’s just kind of get it right next time’. “For them to put their hands and say there were some penalties that needed to be addressed, I thought that was a brave decision. “But we can’t have it again. We can’t have a race and then five hours later you have that degree of change in the result.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Lando Norris says Just Stop Oil protest at Silverstone would be ‘stupid’ Don’t put your life in danger – British GP boss has stark warning for protesters Max Verstappen refuses to ponder title hat-trick despite another emphatic win

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