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Earnings reports from the big three online travel companies showed that consumers are willing to swallow higher prices

A Mexican Supreme Court ruling that invalidated all federal criminal penalties for abortion continued a regional trend of widening access to the procedure, but left in place a patchwork of varying state restrictions

Beloved cartoon characters like Snoopy and SpongeBob SquarePants are taking to the skies above New York City in the annual Macy’s Thanksgiving Day Parade

Bats could hold the key to unlocking new ways to combat cancer, a new study suggests. A paper published by Oxford University Press, looks at the rapid evolution of bats for their abilities to both host and survive infections such as Covid-19 as well as cancer. The animals are known to have a strong immune system which helps fight off many viruses and diseases. These mammals are also thought to have played a role in the emergence of Covid-19 and scientists say such characteristics are interesting to investigate due to the implications it might have on human health. According to the research, understanding the mechanisms of the bat’s immune system that allows these animals to fight off viral infections – may pave the way to understanding how to prevent disease outbreaks from animals to people. To conduct the study, researchers sequenced the genomes of two bat species - the Jamaican fruit bat and the Mesoamerican mustached bat. The team used advanced technology from Oxford Nanopore Technologies and bat samples collected by the American Museum of Natural History in Belize. They then compared the bat genomes to those of other mammals. The results revealed that bats possessed genetic adaptations in proteins which are related to DNA repair and cancer suppression. It was found that bats had adaptations in six DNA repair-related proteins and 46 cancer-related proteins. The study also found that bats had more than double the number of altered cancer-related genes compared to other mammals, which provided further evidence that they have the ability to suppress cancer. “By generating these new bat genomes and comparing them to other mammals we continue to find extraordinary new adaptations in antiviral and anticancer genes,” said the paper’s lead author, Armin Scheben. “These investigations are the first step towards translating research on the unique biology of bats into insights relevant to understanding and treating ageing and diseases, such as cancer, in humans.” The results open up new paths for understanding and studying the links between cancer and immunity, which offers hope that these insights from bats might possibly lead to new treatments for human illnesses. According to the United States Department of the Interior, there are over 1,400 species of bats worldwide and are mostly found in extreme deserts and polar regions. In the US and Canada, there are about 45 species of bats. Read More British bats ‘can help identify coronaviruses with potential to infect humans’ Coronavirus origins still a mystery 3 years into pandemic Groundbreaking migraine treatment offers ‘new hope’ for patients World Sepsis Day: What is the condition and its symptoms? Duran Duran’s Andy Taylor says he’s ‘asymptomatic’ after end-of-life diagnosis

By Rajesh Kumar Singh CHICAGO Shifting travel patterns by consumers in a post-pandemic world are forcing airlines to

Andrew Tate recalls his father, Emory, throwing away his Nintendo even after writing a two-page apology letter

Today show star Jill Martin has been diagnosed with breast cancer. On 17 July, the 47-year-old lifestyle contributor revealed on Today that she had been diagnosed with breast cancer, just one week after she tested positive for the BRCA gene – inherited gene mutations that can increase the risk of developing breast cancer. In an essay shared to Today.com, the TV presenter explained that she learned of her diagnosis on 26 June. Her doctor had recently suggested she get genetic testing due to her family history with breast cancer, which revealed she had tested positive for the BRCA2 gene. Martin elected to undergo preventive bilateral mastectomy, because she had a 60 to 90 per cent chance of developing breast cancer. However, less than a week later, an MRI scan revealed that she had already developed breast cancer. “I am telling this story now because I couldn’t go through months of operations, and start to recover both physically and mentally, without shouting from the rooftops telling everyone to check with their doctors to see if genetic testing is appropriate,” Martin wrote in her essay. The BRCA genes – an abbreviation for “BReast CAncer gene” – are two different genes that have been found to impact a person’s chances of developing breast cancer. There are two BRCA genes, BRCA1 and BRCA2, which normally help repair DNA breaks that can lead to certain cancers. However, when there is a mutation in the BRCA gene, it can no longer be effective in preventing breast cancer. According to the National Breast Cancer Foundation, the carrier of the mutated gene can also pass a gene mutation down to their offspring. It’s been found that people with a BRCA1 or BRCA2 mutation have a higher risk of being diagnosed with breast cancer. It’s estimated that 55 to 65 per cent of women with the BRCA1 mutation will develop breast cancer before age 70, while approximately 45 per cent of women with a BRCA2 mutation will develop breast cancer by age 70. Martin revealed that she will be having a double mastectomy, which will then determine her treatment plan moving forward. After her surgery, she also plans on having her ovaries and fallopian tubes as part of the preventative surgery process, because her chances of getting ovarian cancer are now 20 per cent higher, Martin said. “By the time I recover from my first surgery, I hope that many of you will know your results and can make proactive decisions with your doctors, families and loved ones,” she said. “That is the silver lining to this mess for me. It is what is keeping me going and giving me strength.” The Today show contributor explained that, although she had a clear mammogram test back in January, her mammogram still missed the presence of breast cancer that was later picked up by the MRI scan. “I am talking about this not to scare you, but to raise awareness so that maybe you can be tested and identify a BRCA or other genetic mutation earlier,” Martin wrote. “If I had known I was BRCA positive, I would have gotten screened more regularly, with an MRI alternating with my mammograms.” “What I didn’t know before this experience was that an MRI can pick up cancers that mammograms miss,” she continued. “So while my mammograms missed the presence of breast cancer, an MRI might have helped me catch it earlier.” Mammograms miss one in eight breast cancers, according to the American Cancer Society. For those who test positive for the BRCA gene, the American College of Obstetricians and Gynecologists recommendeds screening for breast cancer with an MRI starting at age 25, and mammograms at age 30. Martin added that earlier testing might have allowed her “the opportunity to have preventative surgery,” she said, “which is something I had planned to do only days before I found out that I actually had cancer.” She wrote: “Different people cope in different ways; for me, I am not hiding under the covers crying. Instead, I want to do everything I can to beat this and protect my family.” Read More Sarah Ferguson says late Queen’s corgis were unimpressed by her post-breast cancer surgery recuperation Country star Morgan Wade reveals plans for double mastectomy after testing for breast cancer gene Former NBC anchor reveals she underwent mastectomy after testing positive for gene that increases cancer risk Sarah Ferguson says corgis were unimpressed by her post-surgery recuperation Sarah Ferguson sweetly honours Queen Elizabeth’s memory amid cancer diagnosis Sarah Ferguson says breast cancer diagnosis was ‘scary’ for Eugenie and Beatrice

A grandmother who was diagnosed with a rare cancerous tumour after her ankle “looked a bit swollen” had to have her leg amputated, but she is now walking with a prosthetic and has achieved her goal of waltzing again with her husband. Shirley Parnell, 75, a retired production coordinator, who lives in Kings Langley, Hertfordshire, with her husband, Lawrence, 76, a retired chartered surveyor, noticed a lump on her ankle in July 2022, and little did she know, it would lead to a devastating diagnosis. Shirley “assumed it would be something that (doctors) could fix”, but, after several scans, she was diagnosed with spindle cell sarcoma, a rare malignant cancerous tumour, and was told a leg amputation would be the only way forward. The mum of two and grandmother of two felt “shocked and in disbelief” as it “hadn’t even crossed (her) mind” that she was going to be diagnosed with cancer. After the surgery, Shirley had an “overwhelming sense of relief” and focused on getting better – to motivate herself, she set herself the goal of being able to dance with her husband again. But, while learning to walk again, Shirley was diagnosed with metastasis lung cancer and could not help but feel “a little bit cheated” as her parents lived until their 90s and she now knows “that’s probably not going to happen.” She did not let this get in the way of her achieving her goal, and in the middle June 2023, she danced with her husband again at a friend’s wedding and said she “had a real sense of achievement”. In July 2022, Shirley got her first warning sign of cancer when she experienced pain in her right ankle. Shirley told PA Real Life: “My ankle started to look a bit swollen – at first, I didn’t think anything of it as I assumed I had just knocked it on something in the house and not realised, but then I noticed a lump. “The lump kept moving around and the pain started to get more intense. So much so that I decided to go and see my local GP.” Shirley’s GP thought it could be a blood clot, so she was prescribed cream and tablets, but after a week, nothing improved. She was then referred to Watford General Hospital for a blood test and an X-ray. Shirley said: “I had just assumed it would be something that they could fix with some medication and the thought of something more serious didn’t really cross my mind. “It was only when they said that the X-ray had come back showing some abnormalities and they wanted me to have an MRI scan, a CT scan and a biopsy that I started to worry. “A few weeks went by, and I tried not to think about the results but then I got a call saying the results were back and they wanted to see me, and I just felt like it was going to be bad news.” At the appointment, Shirley was told she had spindle cell sarcoma, a rare malignant cancerous tumour which can develop in the bone or soft tissue. The doctor suggested that the only option for Shirley was to have her leg amputated to remove the tumour. She said: “As he said those words, I felt shocked and disbelief. “I thought at the time, only last week I was living my life normally, doing things I would come to take for granted such as walking to the shops or going to a Pilates class. “It hadn’t even crossed my mind that it might be cancer, let alone that I would lose a limb because of it.” So, on October 24 2022, at the Royal National Orthopaedic Hospital in Stanmore, Greater London, Shirley had the surgery. She said: “I was very nervous going into surgery but funnily enough I was okay once it was done. “I just had an overwhelming sense of relief that that part was finished. “Everyone has always said to me that I am a very determined person and after the surgery, I just started to look to the future as I felt everything was getting better, so I focused on working towards that.” But, once her leg was amputated, Shirley could not help but feel like she had lost some independence. She said: “Before I could just pop out to pick up some essentials but I had to rely on others to help me, something I am learning to get better at. “I’m so grateful for my husband running me around though.” On January 27 2023, Shirley had a cast made for her prosthetic leg, and it was fitted a week later. She said: “Then came the long and challenging journey of learning how to walk again. “The staff at the Prosthetic Rehabilitation Unit at the Royal National Orthopaedic Hospital were amazing and their support was what got me through those first few weeks and helped me get used to my new way of moving. “I felt strange but excited with my new leg – it felt like it was a real step forward into being more independent.” When in physiotherapy, Shirley made it her goal to be able to dance at her friend’s wedding with her husband. She said: “My husband and I always loved dancing – he joked that we’ll be doing a jive, but I said maybe a slow waltz.” But, at the end of April 2023, she was diagnosed with lung cancer. She said: “My parents lived until they were well into their 90s and I’ll be honest, I fully accepted with my family history that I would do the same. “So it came as a bit of a shock that I now know that that’s probably not going to happen. “I felt a little bit cheated, I suppose, but the other thing it has made me realise is that there are people a lot worse off than me.” Determined not to let the diagnosis impact her goal, Shirley practised walking even more, and at the middle June 2023, they danced together at the wedding. She said: “It was wonderful, I had a real sense of achievement, and being able to have a few dances during the evening was wonderful. “My husband was really proud of me too. “My family have been unbelievably supportive, I can’t thank them enough. “They were so happy for me that day.” Now, Shirley remains under the hospital’s care, having regular scans, and has since passed her driving assistance test. She is also raising money for the Royal National Orthopaedic Hospital Charity for its Impossible Possible campaign. Looking back on the last few years, she said: “I appreciate things a lot more now – I take time to appreciate my garden, the flowers blossoming, and my family. “I feel so lucky that I could have the amputation, and it puts things into perspective definitely.” Read More Mother reveals bruise on her toddler’s eye led to cancer diagnosis Jonnie Irwin details experience with palliative hospice care Ben Cohen’s ex-wife says she had only ‘one symptom’ before cancer diagnosis What is cardiac arrest? The condition that LeBron James’ son suffered from Mom left ‘appalled’ after water park says she can’t breastfeed son in lazy river Government has more work to do to ensure families secure quality childcare – MPs

HAMPTON, Va. & ALPHARETTA, Ga.--(BUSINESS WIRE)--Aug 17, 2023--

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Is it just us, or does tennis feel more relevant than ever right now — and by extension, do tennis outfits feel like they're finally getting their day in the athleisure sun? Besides the fact that tennis is one of the most popular sports around, the U.S. Open is in full swing and giving us plenty of opportunities to daydream about our own tennis whites.