Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

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Sebastian Vettel revealed he “has some ideas” about a return to Formula 1 in some capacity in the future. The 36-year-old retired from the sport after the 2022 season, leaving a lasting legacy with his four championship triumphs with Red Bull from 2010-2013. The German, who also raced for Ferrari and Aston Martin, is a climate change activist and campaigner and regularly spoke out about environmental issues towards the end of his career. Now, Vettel admits that he would be open to a return to F1 down the line, hinting that the sport’s sustainability could be a potential avenue. “We’ll see but I have some ideas,” Vettel said, when asked about a return to the sport whilst appearing at the Goodwood Festival of Speed on Sunday. “I’ve been to Monaco earlier this year. I had a very good meeting with Stefano [Domenicali, F1 CEO]. “Other than obviously the cars directly polluting, F1 has a huge responsibility because it’s a very big event. A lot of people attend, I think you had around 500,000 people at the British Grand Prix last weekend. “So there’s a lot more to it than just the cars but obviously the cars, everybody sees them. It’s important that it’s headed in the right direction. “But I’m talking and I have some ideas. Obviously, we’ll see what the future brings. I think sooner or later, I will probably figure it out and take on a new challenge.” Vettel drove exclusively with e-fuels during his drive of Nigel Mansell’s 1992 Williams car and Ayrton Senna’s 1993 McLaren at Goodwood. The four-day festival was impacted by heavy winds, forcing the cancellation of Saturday’s event, but it concluded without issue on Sunday. Read More How does Max Verstappen and Red Bull compare to the greats of Formula One? Mick Schumacher to drive father Michael’s car at Goodwood Festival of Speed Red Bull has handed Daniel Ricciardo the first step to Sergio Perez’s seat Daniel Ricciardo returns to F1 as he replaces Nyck de Vries The moment Norris came of age in British Grand Prix – and it wasn’t his super start

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