Using MRI scans to screen men for prostate cancer could reduce deaths from the disease “significantly”, researchers have suggested. Scientists said current tests, which detect the level of the protein prostate-specific antigen (PSA) in the blood, have been linked to over-diagnosis and over-treatment of low-risk cancer. Prostate cancer is the most common cancer found in men and, at the moment, those aged over 50 can request a PSA test if they are experiencing symptoms. The Reimagine study invited 303 men aged between 50 and 75 to have a screening MRI and a PSA test. Of the total, 48 (16 per cent) had an MRI that indicated the presence of prostate cancer despite having a median PSA density. Of the group, 32 had lower PSA levels than the current screening benchmark of 3ng/ml, meaning they would not have been referred for further investigation. After NHS assessment, 29 men were diagnosed with cancer that required treatment, 15 of whom had serious cancer and a PSA of less than 3ng/ml. Three men (1 per cent) were diagnosed with low-risk cancer that did not require treatment. Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early Prof Caroline Moore The study was led by University College London, University College London Hospitals NHS Foundation Trust and King’s College London and is published in medical journal BMJ Oncology. Prof Caroline Moore, consultant surgeon at UCLH, chief investigator of the study and NIHR research professor, said the findings are “sobering” and “reiterates the need to consider a new approach to prostate cancer screening”. “Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early, with the added benefit that less than 1 per cent of participants were ‘over-diagnosed’ with low-risk disease,” she added. Prof Mark Emberton, consultant urologist at UCLH, said: “The UK prostate cancer mortality rate is twice as high as in countries like the US or Spain because our levels of testing are much lower than other countries. “Given how treatable prostate cancer is when caught early, I’m confident that a national screening programme will reduce the UK’s prostate cancer mortality rate significantly. There is a lot of work to be done to get us to that point, but I believe this will be possible within the next five to ten years.” Nick James, a professor of prostate and bladder cancer research at the Institute of Cancer Research in London said the study “further reinforces the value of MRI in the diagnostic pathway for prostate cancer”. “The well-known limitations of the old PSA-based screening studies of over- diagnosis and linked over-treatment are increasingly mitigated by the use of MRI,” he added. “Similarly, MRI can also spot cases of prostate cancer in patients with normal PSA levels, who would have been missed using PSA only screening programmes.” MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively Simon Grieveson, Prostate Cancer UK Prof Sir Mike Richards, chairman of the UK National Screening Committee (NSC), said the organisation does not currently recommend prostate cancer screening “because there is no clear evidence that the benefits outweigh the harms”. However, it is preparing to look at various proposals. He added: “The UK NSC will soon commission a major piece of work to consider six prostate cancer screening proposals that were submitted during its annual call for topics. “These include targeted and risk-stratified screening proposals for screening groups of men at higher risk due to factors such as ethnicity and family history.” Simon Grieveson, assistant director of research at Prostate Cancer UK, said: “MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively. “These results are extremely exciting, and we now want to see much larger, UK-wide studies to understand if using MRI as the first step in getting tested could form the basis of a national screening programme.” Another trial, known as Limit, is being conducted with a much larger number of patients, which the research team said is the “next step towards a national prostate screening programme”. The trial will also attempt to recruit more black men, after the team behind Reimagine found they were much less likely to respond to the invitation to screening than others. Saran Green of King’s College London said: “One in four black men will get prostate cancer during their lifetime, which is double the number of men from other ethnicities. “Given this elevated risk, and the fact that black men were five times less likely to sign up for the Reimagine trial than white men, it will be crucial that any national screening programme includes strategies to reach black men and encourage more of them to come forward for testing.”

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Organisers of the Las Vegas Grand Prix are facing a class action lawsuit following the farcical start to this weekend’s race on the strip. Formula One sold the sport’s Sin City comeback after four decades away as the greatest show on Earth. But fans witnessed just eight minutes of practice on Thursday after a drain cover broke free and tore a hole into the underbelly of Carlos Sainz’s Ferrari. The second running was delayed by two-and-a-half hours, and took place in front of vacant grandstands as furious fans were ejected to comply with local employment laws. Practice finished at 4am on Friday morning. Spectators who held a 200 US dollar (£160) general admission ticket for Thursday’s two practice sessions have since been offered a voucher for the same amount to be redeemed on merchandise. But those in attendance on a three-day pass – the cheapest of which is 500 US dollars (£400) – will not receive any compensation. On Friday, Nevada-based Dimopoulos Law Firm and co-counsel JK Legal & Consulting filed a lawsuit with the Nevada District Court seeking damages for the 35,000 paying spectators. “We will vindicate the rights of the fans that travelled great distances and paid small fortunes to attend, but were deprived of the experience,” said Dimopoulos Law Firm owner Steve Dimopoulos in a statement. A spokesperson for Las Vegas Grand Prix said: “We cannot comment on the litigation. “Our focus is on ensuring that our fans have an entertaining experience in a safe and secure environment which is always our top priority.” Earlier, F1 chief executive Stefano Domenicali stopped short of issuing an apology in a 650-word joint statement with CEO of the Las Vegas race, Renee Wilm. “We have all been to events, like concerts, games and even other Formula One races, that have been cancelled because of factors like weather or technical issues,” they said. “It happens, and we hope people will understand.” The maiden race on the Las Vegas strip gets underway at 10pm local time on Saturday (6am GMT on Sunday). Read More Toto Wolff fuelled by ‘personal anger’ to help Lewis Hamilton win eighth title On this day in 2010: Sebastian Vettel becomes youngest ever F1 world champion What Charles Leclerc needs to claim victory from pole in first Las Vegas Grand Prix What Charles Leclerc needs to claim victory from pole in first Las Vegas Grand Prix F1 2023 season race schedule: When is the Las Vegas Grand Prix? Verstappen criticises Vegas GP: ‘Monaco is Champions League, this is National League’

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Max Verstappen topped a rain-interrupted final practice session for Sunday’s Dutch Grand Prix. The concluding hour before qualifying was red-flagged on three occasions following a series of accidents in the tricky conditions at Zandvoort. With the session a little more than 10 minutes old, Kevin Magnussen spun out in his Haas at Turn 3, before Zhou Guanyu beached his Alfa Romeo at the penultimate corner. Liam Lawson – the New Zealander making his Formula One debut as a replacement for Daniel Ricciardo who suffered a broken wrist in practice – then performed a pirouette heading into the main straight. Lawson, 21, grazed the tyre wall on the opposing side of the circuit which led to a third stoppage. When the action resumed, Verstappen, who is bidding to equal Sebastian Vettel’s record of nine consecutive victories, set an impressive pace in front of his home crowd. The Red Bull driver finished three tenths clear of George Russell, with the Mercedes driver the only man within one second of Verstappen. Sergio Perez took third spot, one place ahead of Aston Martin’s Fernando Alonso with Lewis Hamilton fifth for Mercedes. Qualifying takes place at 3pm local time (2pm BST) with the unsettled weather conditions forecast to continue throughout the day. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

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