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A new survey has found that nearly half of adults in the United States are interested in taking prescription drugs for weight loss, such as Ozempic or Wegovy. In a KFF health tracking poll published on 3 August, researchers reported that 45 per cent of adults said they’d be interested in taking a “safe and effective” prescription drug for weight loss. Meanwhile, seven in 10 adults said they’ve heard at least “a little” about a new class of drugs being used for weight loss, with about one in five saying they have heard “a lot” about these drugs. Ozempic is a type 2 diabetes medication known for its weight loss side effects. Similar semaglutide injections, such as Wegovy and Mounjaro, have been specifically approved for the treatment of obesity and weight loss. This class of drugs called GLP-1 agonists works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), regulating blood sugar levels and slowing down the rate at which food leaves the stomach to create the feeling of fullness. Of the US adults surveyed, older groups were some of the most aware of prescription weight loss drugs, with 76 per cent being those who have been told by a doctor in the past five years that they are overweight or obese. Nearly 60 per cent of those surveyed said they were currently trying to lose weight as well. While there was an overall interest in taking a prescription weight loss drug, that interest significantly decreased when people were asked whether they would take the medication as a routine injection. Only 16 per cent of adults said they would still take Ozempic or Wegovy, even if it wasn’t covered by their health insurance and was not specifically approved by the US Food and Drug Administration for weight loss. In fact, most people believed that insurance companies should cover the cost of weight loss drugs for adults who are overweight or obese, with an overwhelming 80 per cent of adults. Additionally, a large majority of adults believed the substantial profits that pharmaceutical companies have made from increased demand for weight loss drugs is a major factor contributing to the cost of injections like Ozempic and Wegovy. According to Novo Nordisk, the pharmaceutical company behind these prescription drugs for diabetes and weight loss, the list price for Ozempic can cost $935.77 per month without health insurance. Although the majority of adults said they trust pharmaceutical companies like Novo Nordisk to provide “reliable information” about safety and side effects of GLP-1 agonists, only 22 per cent said they trust these companies to price their products fairly. The FDA has listed the most common side effects of taking Wegovy as nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, and digestive disorders. More serious complications can occur from use of Wegovy or Mounjaro, such as the “potential risk of thyroid C-cell tumours,” pancreatitis, gallbladder problems, acute kidney injury, increased heart rate, and suicidal behaviour or thinking. Taking Ozempic can also lead to possible thyroid tumours, including cancer, pancreatitis, changes in vision, and kidney and gallbladder problems. Recently, several patients reported suffering from severe gastroparesis, also known as stomach paralysis, after taking the prescription weight loss medications. In a report from CNN, two people claimed that their “stomachs are paralysed” after taking Ozempic. “I wish I never touched it. I wish I’d never heard of it in my life,” Joanie Knight, a 37-year-old from Louisiana, told CNN. “This medicine made my life hell. So much hell. It has cost me money. It cost me a lot of stress; it cost me days and nights and trips with my family. It’s cost me a lot, and it’s not worth it. The price is too high.” One woman was also diagnosed with cyclic vomiting syndrome, which causes her to throw up multiple times a day. “I’ve almost been off Ozempic for a year, but I’m still not back to my normal,” said Emily Wright, a 38-year-old teacher from Toronto. Shortly after the report, the FDA shared in a statement with The Independent that it has become aware of stomach paralysis occurring among patients taking the medications. “The FDA has received reports of gastroparesis with semaglutide and liraglutide, of which some documented the adverse event as not recovered after discontinuation of the respective product at the time of the report,” the agency said. However, officials clarified that they were unable to determine whether taking Ozempic or Wegovy was the cause of stomach paralysis, or if it was caused by a different issue. “Gastroparesis can be a complication of diabetes that is related to long-standing or poorly controlled disease, further complicating the ability to determine what role the drugs played in the reported events,” the FDA added. In response to reports of stomach paralysis, drug manufacturer Novo Nordisk noted that these medications have been used to treat type 2 diabetes “for more than 15 years”, and for the “treatment of obesity” for eight years. “Semaglutide has been extensively examined in robust clinical development programs, large real world evidence studies and has cumulatively over 9.5 million patient years of exposure,” a spokesperson for Novo Nordisk said in a statement to The Independent. “Gastrointestinal (GI) events are well-known side effects of the GLP-1 class. For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. GLP-1’s are known to cause a delay in gastric emptying, as noted in the label of each of our GLP-1 RA medications. Symptoms of delayed gastric emptying, nausea and vomiting are listed as side effects.” Read More Obese people on weight-loss jabs ‘should be prepared to stay on them for life’ Ozempic users report stomach paralysis as weight loss drug side effect: ‘I wish I never touched it’ Sharon Osbourne says she was ‘nauseous’ for weeks after taking Ozempic to lose weight Sharon Osbourne reveals what Ozempic did to her when she was taking it Ozempic users report stomach paralysis as side effect: ‘I wish I never touched it’ Lorraine Candy: ‘Perimenopausal rage made me unravel’

This month marks the start of the autumn/winter fashion season and it’s also Second Hand September, Oxfam’s annual event encouraging consumers to avoid buying new items for 30 days. You don’t have to go rummaging through charity shops or car boot sales if you want to refresh your wardrobe for autumn or stock up on basics – there’s now a swathe of amazing sites that let you shop for pre-loved clothes from the comfort of your own home. By saying no to new, you can help prevent good quality garments from going to landfill and save money when you bag a bargain for a fraction of what it would have cost originally – and you’re spoilt for choice when it comes to pre-owned clothes shopping online. From resale platforms where users list their unwanted or unworn garments to vintage and designer-focused e-commerce retailers, here’s our pick of the best secondhand fashion sites… Vinted A peer-to-peer marketplace with a community of 75 million across the world, Vinted lets you buy direct from other users. The site has become so popular you might find the sheer array of products overwhelming at first. The key is to filter as much as possible. Try narrowing search results down by ticking the brands you usually buy on the high street (and avoiding the ones you don’t like), then sorting by price to find the cheapest options. Depop Hugely popular with Gen Z fashion obsessives, Depop is the go-to site for current trends, upcycled pieces and the latest vintage finds. Listings show how long ago an item was uploaded, so if it’s been on the site for a while you can try offering a lower price to the seller. Facebook Marketplace Connecting buyers and sellers in the same area, Facebook Marketplace is often the go-to site for people looking to clear out an overstuffed wardrobe or get rid of clothes when moving house. You just need a Facebook account to log in. Payment is completed via Messenger and you can arrange local pick-up or delivery (if the user offers that option). As well as individual items, look out for sellers offloading bundles of clothing in one size. eBay Having partnered with Love Island and appointed two former islanders as pre-loved ambassadors, online shopping behemoth eBay wants to be known as a leader in sustainable fashion. To simplify secondhand clothes shopping, the site now has a dedicated pre-loved fashion hub, where you can find items grouped by brand, trend, season, occasion, and more. ASOS Marketplace Focusing on the latest looks, ASOS Marketplace hosts independent brands and vintage boutiques – so make sure to tick the ‘vintage’ option under ‘condition’ when browsing for secondhand items. Charity shop sites While it’s great to support your local charity shops, you can also find some brilliant bargains and hand-picked premium pieces on charities’ online stores. Oxfam and Shelter have dedicated sites, while British Heart Foundation and British Red Cross have eBay shops. Vintage retailers If you’re lacking any decent vintage boutiques near you, don’t worry, because some of the biggest names in the game have online stores packed with gems from days gone by. Check out well-known brands like Beyond Retro and Rokit for retro threads dating as far back as the 1940s. Designer resale sites In the last few years, a crop of slick websites has popped up to serve shoppers hunting for secondhand luxury fashion. Head to sites such as Vestiaire Collective, Sellier, Lampoo and The Cirkel for designer clothes and accessories from brands like Burberry, Chanel, Gucci, Fendi and many more. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live What are gynaecological cancers and how can you prevent them? Alzheimer’s: How and when to talk to someone about their memory loss As Simon Cowell shares positive therapy experience, how can it help even if you aren’t in crisis?

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