Using MRI scans to screen men for prostate cancer could reduce deaths from the disease “significantly”, researchers have suggested. Scientists said current tests, which detect the level of the protein prostate-specific antigen (PSA) in the blood, have been linked to over-diagnosis and over-treatment of low-risk cancer. Prostate cancer is the most common cancer found in men and, at the moment, those aged over 50 can request a PSA test if they are experiencing symptoms. The Reimagine study invited 303 men aged between 50 and 75 to have a screening MRI and a PSA test. Of the total, 48 (16 per cent) had an MRI that indicated the presence of prostate cancer despite having a median PSA density. Of the group, 32 had lower PSA levels than the current screening benchmark of 3ng/ml, meaning they would not have been referred for further investigation. After NHS assessment, 29 men were diagnosed with cancer that required treatment, 15 of whom had serious cancer and a PSA of less than 3ng/ml. Three men (1 per cent) were diagnosed with low-risk cancer that did not require treatment. Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early Prof Caroline Moore The study was led by University College London, University College London Hospitals NHS Foundation Trust and King’s College London and is published in medical journal BMJ Oncology. Prof Caroline Moore, consultant surgeon at UCLH, chief investigator of the study and NIHR research professor, said the findings are “sobering” and “reiterates the need to consider a new approach to prostate cancer screening”. “Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early, with the added benefit that less than 1 per cent of participants were ‘over-diagnosed’ with low-risk disease,” she added. Prof Mark Emberton, consultant urologist at UCLH, said: “The UK prostate cancer mortality rate is twice as high as in countries like the US or Spain because our levels of testing are much lower than other countries. “Given how treatable prostate cancer is when caught early, I’m confident that a national screening programme will reduce the UK’s prostate cancer mortality rate significantly. There is a lot of work to be done to get us to that point, but I believe this will be possible within the next five to ten years.” Nick James, a professor of prostate and bladder cancer research at the Institute of Cancer Research in London said the study “further reinforces the value of MRI in the diagnostic pathway for prostate cancer”. “The well-known limitations of the old PSA-based screening studies of over- diagnosis and linked over-treatment are increasingly mitigated by the use of MRI,” he added. “Similarly, MRI can also spot cases of prostate cancer in patients with normal PSA levels, who would have been missed using PSA only screening programmes.” MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively Simon Grieveson, Prostate Cancer UK Prof Sir Mike Richards, chairman of the UK National Screening Committee (NSC), said the organisation does not currently recommend prostate cancer screening “because there is no clear evidence that the benefits outweigh the harms”. However, it is preparing to look at various proposals. He added: “The UK NSC will soon commission a major piece of work to consider six prostate cancer screening proposals that were submitted during its annual call for topics. “These include targeted and risk-stratified screening proposals for screening groups of men at higher risk due to factors such as ethnicity and family history.” Simon Grieveson, assistant director of research at Prostate Cancer UK, said: “MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively. “These results are extremely exciting, and we now want to see much larger, UK-wide studies to understand if using MRI as the first step in getting tested could form the basis of a national screening programme.” Another trial, known as Limit, is being conducted with a much larger number of patients, which the research team said is the “next step towards a national prostate screening programme”. The trial will also attempt to recruit more black men, after the team behind Reimagine found they were much less likely to respond to the invitation to screening than others. Saran Green of King’s College London said: “One in four black men will get prostate cancer during their lifetime, which is double the number of men from other ethnicities. “Given this elevated risk, and the fact that black men were five times less likely to sign up for the Reimagine trial than white men, it will be crucial that any national screening programme includes strategies to reach black men and encourage more of them to come forward for testing.”

We live in a time where information about our favorite celebrities is readily available — the clothes they wear, their skin-care regimens, workout routines, the recipes they use, where they vacation, and so much more. So, it’s only natural that we’d be curious about their sex toy preferences. After all, sexual pleasure is a purchase we can all stand behind, and female celebrities have long been at the forefront of erasing the lonely girl stigma that formerly surrounded purchasing vibrators — because putting your own pleasure first should never be stigmatized.

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The source has also revealed that Al Pacino has shunned his friends and family after he learned that his girlfriend Noor Alfallah, 29, was pregnant

“Television is art,” screenwriter Sierra Teller Ornelas tells Refinery29 Somos. “It’s not meant to be made like a car.” If anyone knows the amount of creativity required for television writing, it’s her. She’s spent the last decade working on television shows like Brooklyn Nine-Nine and NBC’s Superstore, including leading her own production in Peacock’s much-loved but short-lived Rutherford Falls. She was recently developing a Latine sitcom for NBC called Amigos, but she’s not working now — she, along with thousands of others, is on strike with the Writers Guild of America (WGA). And this week, the group was recently joined by the 160,000-person-strong actor union, SAG-AFTRA.

It’s a tale as old as time: The moment the sun is high in the sky, we want our hair to look suitably sun-kissed. It could be something minimal like the trending “Scandi hairline” trick (a bleaching technique that brightens the baby hairs around the face) or something like “glow lights” (varying tones of blonde that add a natural luminescence to the hair). Wherever you land, the association between warmer weather and lighter blonde remains steadfast.

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CANNES, France (AP) — The Cannes Film Festival opened its 76th edition with a parade of stars, including the much-debated return of Johnny Depp.

Anne Hathaway arrived at the inaugural Albie Awards in an iconic look: A Versace gown that was first worn by Claudia Schiffer at this year’s Milan Fashion Week. On 28 September, the actor, 40, was one of many stars that attended the awards ceremony, which is hosted by Amal and George Clooney’s organisation, The Clooney Foundation For Justice, and is “a homage to those whose fearless devotion to human rights deserves admiration and support”. For the occasion, Hathaway wore the floor-length dress, which features a green and metallic checkerboard design print. The look also featured a green lace neckline and thin spaghetti straps. For accessories, she opted for a silver pendant necklace, bracelets, and earrings, paired with matching silver heels, while she chose to wear her hair in a half-up half-down style. Earlier this month, the dress by Donatella Versace first debuted at Milan Fashion Week, when Schiffer walked the runway in the outfit. Similar to the Princess Diaries star, the German supermodel wore the dress with a pair of silver heels. In an Instagram post shared by Vogue and Versace, the two brands celebrated the launch of the dress, as well as Schiffer’s appearance on the runway. “Today during #MilanFashionWeek, @donatella_versace debuted her spring 2024 collection to a star-studded audience. One of the most special guests? Legendary supermodel @claudiaschiffer, who closed the show wearing a dazzling green gown,” Vogue wrote in the caption of the post, which included a video of Schiffer during the event. This isn’t Schiffer’s first time working with Versace. Back in 2017, she walked the runway for the brand’s spring show at Milan Fashion Week with fellow modelling legends Cindy Crawford, Naomi Campbell, Carla Bruni, and Helena Christensen. For the occasion, the group of models all wore matching sheer, gold dresses. Meanwhile, Hathaway has continued to work with the luxury fashion brand, as she revealed in April that she is the face of Versace’s Icons collection campaign. Along with sharing snaps of herself for the brand on Instagram, she also explained how she first heard about the campaign idea from the fashion designer. “When the brilliant and talented @donatella_versace approached me for this campaign, she shared her vision of a timeless collection with the trademark @versace edge,” the actor wrote on Instagram in April. “She said she wanted to focus on pieces designed to be a cherished part of one’s wardrobe, enjoyed outside the trend cycle, worn again and again throughout your life.” As part of the campaign, Hathaway and Donatella Versace also hosted the Versace Icons Dinner in New York City earlier this week. According to an Instagram post shared by the luxury fashion house, the dinner was a celebration of icons who are “rising up from all corners of the globe and representing a broad spectrum of cultures, industries, identities and ethnicities”. “Icons are artists, entrepreneurs, actors, human rights advocates, musicians, creatives and ambassadors of social change,” the brand wrote. “Icons are storytellers, driven by passion, purpose and a desire to connect and share. Icons emerge from the most unexpected of circumstances. Their success lies in their ability to transform the everyday into the extraordinary, to use their voices and platforms confidently and for good.” The evening also consisted of a star-studded guest list, which included Ariana DeBose, Sheryl Lee Ralph, Cindy Crawford, Helena Christensen, and Rachel Brosnahan. Read More Anne Hathaway shares honest response to fans who say she looks ‘really good’ for her age Anne Hathaway says Gen Z has been her style inspiration Every film and TV series that’s allowed to continue production during SAG-AFTRA strikes Anne Hathaway shares honest response to fans who say she looks ‘good’ for her age Travis Kelce wears ‘1989’ inspired outfit after leaving NFL game with Taylor Swift This is how your make-up needs change as you age