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The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

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Victoria Beckham has said she would not want to be in her twenties again as she used to focus on what she felt needed to be improved upon but now she is “comfortable” with who she is. Beckham rose to prominence in the nineties as a member of girl group The Spice Girls, but later turned her hand to the worlds of fashion and beauty. She said she embraces her look at age 49 but admitted that her husband, former England footballer David Beckham, has never seen her without her eyebrows done. Asked how she feels about ageing, she told The Sunday Times: “I am comfortable with who I am, I accept how I look, I make the best of what I have. “I feel, professionally and personally, really accomplished at 49. I consider how I apply my make-up. But I like how it feels being older. “I wouldn’t want to be 25 again. I was the kind of young woman who would look in the mirror and see what needed to be improved upon, as opposed to what actually looked OK.” She continued: “I’ve always been quite tough on myself, but because of that I’ve also always strived to be the best version of myself. “It’s not about changing anything, it’s just about looking at the best version of yourself.” These days, her signature style is largely removed from the Spice Girls’ heyday and through her eponymous fashion label, she is known for elegant silhouettes with lots of sleek, flowing dresses, palazzo pants and block colours. Beckham revealed she undergoes some laser and skin tightening treatments but underlined that she is “not trying to turn back the clock”. “I think it’s about little things. Same with make-up, it’s about not doing too much, which can be really ageing”, she said. “I went to an event recently and people had very ‘big’ (overfilled) faces. There are some scary options out there.” However, she admitted that she fell victim to the over-plucked eyebrow style and now drawing on her eyebrows is the first thing she does every morning. “Over the years my brows have been so overplucked that if you saw me without it you’d be horrified”, she said. “David has never seen me without my brows. They’re the first thing I do: wake up, put on the brow.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 7 tips and tricks for hay fever relief Top Films: w/c Saturday, May 27 Soap Guide: w/c Saturday, May 27

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It seems that London will finally be given its own version of New York City’s famed Met Gala with Vogue World 2023. On 31 May, Vogue announced the second annual Vogue World extravaganza will arrive in London on 14 September. The fashion and culture spectacular will feature appearances from Stormzy and Michaela Coel, as well as dramatic performances and a runway show to kick off the start of London Fashion Week. The one-evening event will pay tribute to British culture, as all ticket sales will go towards benefiting performing arts organisations throughout London – including the National Theatre, Royal Opera House and Rambert dance company. The show comes after the inaugural Vogue World took place in New York City’s Meatpacking District last year, where A-listers like Serena Williams and Lil Nas X gathered for a street fair and star-studded fashion show. This year’s Vogue World London will be centered around a theatrical production at Theatre Royal Drury Lane, conceived by English director and producer Stephen Daldry. As for the Vogue World 2023 fashion show, the London event will highlight autumn/winter 2023 collections from both emerging British designers and household names. “Our editors have spent so much time at fashion shows over the years, around the world, that we thought, ‘Why not put together one of our own – one that tells a story about the cultural moment we’re in, but through the lens of fashion?’” said Vogue editor-in-chief Anna Wintour in a press release. “New York did that brilliantly well, and now we will be doing it again in London to show our support for the arts,” she continued. “The arts are under threat in the UK and Vogue World will be a timely reminder of how important they are, how vital a part of our lives, and how much they need our support.” Meanwhile, British Vogue editor-in-chief Edward Enninful added: “British Vogue has been championing fashion, culture, and the magical point where the two intersect for 107 years. Now, we’re bringing its pages to life with the help of industry-leading talents in order to support the full spectrum of the creative arts in London. I can’t wait for everyone to join us at Theatre Royal Drury Lane for a night to remember.” On Instagram, Vogue shared several promotional photos and videos for Vogue World 2023 featuring Naomi Campbell, Victoria Beckham, Sir Ian McKellan, and London’s mayor Sadiq Khan. Anna Wintour will oversee Vogue World 2023, much like she did at this year’s Met Gala at the Metropolitan Museum of Art in New York City. The annual fashion red carpet event also raises funds for the museum’s Costume Institute. This year’s Met Gala theme paid tribute to Wintour’s longtime friend and collaborator, Karl Lagerfeld. “Karl Lagerfeld: A Line of Beauty” aimed to “examine the life” of the late designer’s fashion legacy as celebrities were asked to arrive in their best Lagerfeld-inspired looks. Kim Kardashian, Nicole Kidman, Naomi Campbell, and Jennifer Lopez all walked the red carpet in line with the theme, which instructed guests “to wear an archival look from one of the labels Lagerfeld led”. Others took more creative liberties in their Met Gala looks, like Doja Cat and Jared Leto who were dressed as Lagerfeld’s beloved cat, Choupette. Tickets for Vogue World 2023 will go on sale to the general public on Friday 2 June at 10am BST/5am ET. The London event will also be livestreamed on all Vogue sites globally. Read More Anna Wintour and Met curator reveal rule breaks that would lead to celebrities being uninvited from gala Met Gala 2023: Best dressed stars on the red carpet, from Kim Kardashian to Anne Hathaway The 2023 Met Gala has been criticised as ‘so boring’ that a cockroach became a highlight Dame Esther Rantzen faces stage four lung cancer: key facts about the disease Dua Lipa reveals how she bonded with designer Donatella Versace Banging brunch recipes worth getting out of bed for

Lando Norris was highly critical of Sergio Perez after the pair collided in Sunday’s Abu Dhabi Grand Prix, insisting “he crashes into a lot of people.” As the race entered its final stages, Red Bull driver Perez looked to take fourth place from the Brit at turn six, diving down the inside. The pair touched, with Norris taking to the escape road, and Perez was later given a five-second time penalty due to “causing a collision.” McLaren driver Norris was unequivocal afterwards about who was at fault. “I was expecting it to be honest – it was nothing new,” Norris said afterwards. “He crashes into a lot of people so not something new for anyone to know. “But I did give him a lot of space. And so it didn’t change my race at the end of the day. It was a tough day, we just didn’t have the pace we wanted.” Norris finished the race in fifth, with Perez overtaking him comfortably on the next lap. It meant the Brit finished sixth in the drivers’ standings, while McLaren beat Aston Martin to fourth in the constructors’ championship. “I’m still happy we as a team beat Aston Martin, that was our target and we achieved it,” he added. Perez, however, was furious and was given a formal warning after describing the stewards’ decision as a “joke”. The Mexican doubled down on the criticism afterwards: "I think the stewards were very poor today in my opinion. "We’ve seen a lot worse, we touched tyre to tyre, Lando cut the corner and I still had the penalty." Perez, despite dropping from second to fourth as a result of his penalty, comfortably finished second in the drivers’ championship for his best-ever season finish in F1. Read More Williams boss refuses to confirm Logan Sargeant’s seat for 2024 F1 2023 season report card: Red Bull flourish but what about Mercedes and Ferrari? Toto Wolff sees ‘Mount Everest’ ahead as Mercedes seek to end Red Bull’s domination When does the 2024 F1 season start? F1 Abu Dhabi GP LIVE: Race results and reaction at Yas Marina Relegation and promotion in F1? An alternative reality to reinvigorate Abu Dhabi

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A US panel of health experts voted Wednesday in favor of making birth control pills available without a prescription, a move backed by reproductive rights advocates especially in the wake of a Supreme Court...

Iceland’s main tourist attraction, Blue Lagoon, will close its operations for at least a week as an underground