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The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

What: BTS: Yet to Come Where to watch: Prime Video Premiere date: Nov. 9, 2023

Iowa’s Republican-led legislature has enacted a new bill prohibiting the vast majority of abortions after approximately six weeks of pregnancy. This comes just weeks after a deadlock in the Iowa Supreme Court that rendered a six-week abortion ban unenforceable. On Tuesday, however, legislators reconvened at the Iowa State Capitol and successfully passed a nearly identical set of restrictions on the procedure. Republican governor Kim Reynolds plans to sign the bill into law on Friday, her office said. “I believe the pro-life movement is the most important human rights cause of our time,” she said in a statement on Tuesday night. “The Iowa Supreme Court questioned whether this legislature would pass the same law they did in 2018, and today they have a clear answer. The voices of Iowans and their democratically elected representatives cannot be ignored any longer, and justice for the unborn should not be delayed.” Under the new Republican bill, abortions are permitted up until approximately six weeks of pregnancy – a timeframe that critics say could pass before many women are even aware of their pregnancies. The legislation does incorporate exceptions beyond this point, such as in cases of rape or incest, when the woman’s life is at significant risk, when she faces the possibility of certain permanent injuries, or when there are foetal abnormalities deemed “incompatible with life”. “Unborn people, in my opinion, are babies, and the government’s job is to protect the rights of every person, including babies,” Republican representative Brad Sherman said on the House floor. The neighbouring Republican-led states of Missouri, South Dakota and Wisconsin have already implemented stringent abortion bans, effectively prohibiting the procedure in almost all cases. Additionally, Nebraska recently passed a new ban at the 12-week mark. Illinois and Minnesota, which have Democratic leaderships, maintain permissive abortion laws and reports suggested these may emerge as potential destinations for Iowans seeking abortions. “If this bill becomes law, women will die in Iowa. Common sense has walked out the door,” Democrat representative Beth Wessel-Kroeschell told her colleagues on Tuesday night. “The ACLU of Iowa, Planned Parenthood, and the Emma Goldman Clinic remain committed to protecting the reproductive rights of Iowans to control their bodies and their lives, their health, and their safety – including filing a lawsuit to block this reckless, cruel law,” Mark Stringer, the executive director of ACLU’s Iowa chapter, said in a statement. Protesters gathered ahead of the vote at the capitol in Des Moines on Tuesday, holding signs that read “My Body, My Choice” and “Unborn Lives Matter”. Read More Iowa Legislature will take up 6-week abortion ban during special session Tuesday Republican presidential candidates jump to defend Iowa governor from Trump attacks Abortion numbers in Indiana drop amid ‘fear and uncertainty’ of possible state ban Republican presidential candidates jump to defend Iowa governor from Trump attacks Paraguay’s president-elect recommits to ties as Taiwan’s last ally in South America Thailand's Election Commission says top candidate for prime minister may have broken election law

Max Verstappen said he can forget about extending his record winning streak after qualifying only 11th for Sunday’s Singapore Grand Prix. On a wild night under the 1600 bulbs that light up the Marina Bay Circuit, Aston Martin’s Lance Stroll also walked away from a staggering 110mph shunt, while Ferrari’s Carlos Sainz pipped the Mercedes of George Russell to land his second pole position in as many races. Charles Leclerc will start third ahead of Lando Norris and Lewis Hamilton. But it was the demise of Red Bull – the unbeaten tour de force of this most one-sided of seasons – that left those here in shock and awe. Verstappen’s team-mate Sergio Perez also failed to reach Q3. He will line up in 13th for Sunday’s 62-lap race. Verstappen warned earlier this week that the Red Bull machinery which has carried him to a record 10 consecutive victories would not be suited to this unique 3.07-mile high-downforce circuit. Yet, nobody could have foreseen him being sent for an early bath along with Perez in the other car. Verstappen was straight on the radio to express his dismay. “I don’t know if you saw that, but that was just f***** shocking,” he said. “Absolutely shocking experience.” Verstappen’s Red Bull team, without a defeat in the 14 rounds so far, now face an improbable task of making history by becoming Formula One’s first ‘Invincibles’. “You can forget about that (a victory),” said Verstappen. “I don’t want it to sound too dramatic but it has been a tough weekend, and it is a long, long time since it has been like this in qualifying.” Verstappen last started this far back in Saudi Arabia when a driveshaft failure consigned him to 15th at the second round in March. He finished runner-up to Perez. But the streets of Singapore, unlike those in Jeddah, are strenuous to overtake on. Indeed, eight of the last 13 races here have been won from pole. “You cannot pass here,” added Verstappen. “You need to be one and a half, to two or three seconds faster than the car in front which we are not. It will be a very tough and long afternoon. I am confident the car will be fast again in Suzuka next weekend Max Verstappen “On other tracks you can start last and win, but not in Singapore. I want to win, but when it is not possible you have to accept that. “I knew there would be a day that I wouldn’t win. I had a really good run up until now. “And I would always take a season where we are winning as much as we have, and have one really bad weekend, over the other way round when you are not fighting for the championship. I am confident the car will be fast again in Suzuka next weekend.” Red Bull’s sudden malaise cleared the way for Sainz to capture another pole, a fortnight after he secured top spot in qualifying in Monza. However, Russell ran the Spaniard close, finishing just 0.072 seconds back, and the Englishman believes he has a strong chance of landing Mercedes’ first win of the campaign and the second of his career. The Silver Arrows have also followed a unqiue strategy this weekend that leaves Russell with an extra set of medium tyres which could provide him with the tactical edge over Sainz. “George has a really good shot at winning and I really hope he does,” said team-mate Hamilton, who qualified half-a-second back on disappointing evening for the seven-time world champion. “I hope he gets a good start and gets ahead of the Ferraris. That would be amazing for him and for the team. “For me, I will see what I can do. If I get further up then great. I changed the car last night and I don’t know what is going on with it. It is the hardest car I have ever driven to get right.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Lance Stroll cleared to race in Singapore after high-speed qualifying crash Lance Stroll crashes into barrier at 110mph in Singapore Grand Prix qualifying Max Verstappen struggles in Singapore practice under the lights

Max Verstappen handed his rivals the slimmest of hopes that he could be beaten at Sunday’s Hungarian Grand Prix after he finished only 11th in practice. The dominant Dutchman, who has won eight of the 10 rounds so far and six in succession to establish a 99-point lead in the standings, has mastered all conditions this season. But Verstappen unusually ended the sole dry running here six tenths back from Ferrari’s Charles Leclerc, with McLaren’s Lando Norris – fresh from his impressive second place at the British Grand Prix – 0.015 seconds adrift of the scarlet car. Lewis Hamilton was 16th with Mercedes team-mate George Russell 20th and last on a topsy-turvy day at the Hungaroring. Despite Verstappen being off the pace, times in practice must be treated with a degree of caution as different setup and fuel loads are trialled. It is also worth noting that a number of the top teams will have held back fresh rubber following the reduction of tyre allocation from 13 sets to 11 here. Verstappen’s team-mate Sergio Perez took two wins from the opening four, but the Mexican has been on a torrid run since, and his bad form continued when he crashed out of first practice. The opening one-hour running of the weekend was dry and barely a few minutes old when Perez – on his first lap – lost control of his Red Bull and ended up in the wall. The Mexican put two wheels on the grass under braking for the fifth corner, sending him into a pirouette and into the tyre barrier. Perez was unharmed in the accident but he sustained significant damage to the front of his machine. It also denied the rest of the field any dry running as the heavens opened with the red flags deployed to recover Perez’s wounded machine. The 33-year-old is under increasing pressure at Red Bull following five-consecutive qualifying sessions in which he has failed to make it into Q3. On each of those occasions, Verstappen has scored pole position in the other Red Bull. Daniel Ricciardo’s comeback at Red Bull’s junior team AlphaTauri is also likely to be playing on Perez’s mind, with the Australian admitting he is daring to dream about the possibility of a return to the grid’s all-conquering team. Perez was able to take part in the day’s concluding action but he locked up and flat-spotted his front-right tyre and could manage only 18th, 1.3 sec slower than Leclerc. Ricciardo, back in the saddle in place of the sacked Nyck De Vries, has a dozen races to prove he still possesses the prowess which carried him to eight wins. He finished 14th in his first outing since last year’s season-ending Abu Dhabi Grand Prix, seven tenths back and 10 places behind his new team-mate Yuki Tsunoda. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Like someone cut my heart out – Claire Williams on sale of father’s F1 team Daniel Ricciardo dreaming of Red Bull return ahead of F1 comeback How does Max Verstappen and Red Bull compare to the greats of Formula One?

ROSEMONT, Ill.--(BUSINESS WIRE)--Jul 12, 2023--

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Ray Jordan lost control of his head and arms, and his motor functions were gone when his parents rushed him to a hospital