Women with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) tend to have more symptoms and co-occurring conditions than men, according to the world’s largest study of the disease. The study, entitled DecodeME, reveals women who have the condition for more than 10 years are more likely to experience increasingly severe symptoms as they get older. ME/CFS is estimated to affect more than 250,000 people in the UK, of all ages and from all social and economic backgrounds. Its key feature, called post-exertional malaise, is a delayed dramatic worsening of symptoms following minor physical effort. Other symptoms include pain, brain fog and extreme energy limitation that does not improve with rest. Causes are unknown and there is currently no diagnostic test or cure. Experts from the University of Edinburgh analysed anonymous survey questionnaires from more than 17,000 people with ME/CFS. Two-thirds of women, and slightly more than half of men, reported at least one active co-occurring condition. Similarly, 39.2% of women and 28.6% of men reported at least one inactive co-occurring condition. We discovered that the disease is worse for women, in older people, and many years after their ME/CFS started Professor Chris Ponting of the University of Edinburgh A condition was considered active if the participant had experienced symptoms in the preceding six months. The most common active co-occurring condition was irritable bowel syndrome, with clinical depression, fibromyalgia, anaemia and hypothyroidism also featuring prominently. Women also reported, on average, more symptoms than men – 42 compared with 36. The most common of these symptoms were brain fog – a term commonly used to describe the cognitive impairment experienced by participants – unrefreshing sleep and muscle pain. These findings highlight the very serious impact ME/CFS has on women who are disproportionately affected Sonya Chowdhury, chief executive of Action for M.E Participants were also asked to define the severity of their illness from mild to very severe using definitions from the UK’s National Institute for Health and Care Excellence guidelines. Experts identified that being a woman and having ME/CFS for more than 10 years are risk factors for severe illness, with symptoms increasing in intensity as they age. Professor Chris Ponting, study lead from the MRC human genetics unit at the University of Edinburgh’s Institute of Genetics and Cancer, said: “ME/CFS is a devastating disease affecting a UK population the size of Derby. “We discovered that the disease is worse for women, in older people, and many years after their ME/CFS started. “Our hope is that DecodeME’s genetic results will shed light on why certain groups are more susceptible to ME/CFS than others.” Sonya Chowdhury, chief executive of Action for M.E. and chair of the management group of the study, said: “These findings highlight the very serious impact ME/CFS has on women who are disproportionately affected. “It’s important to also recognise the impact that it has on men who have ME/CFS and we thank the 20,000 men and women who have already signed up to take part in this very important study. “We still need more to join us, so if you are 16 or older, live in the UK and have a diagnosis of ME/CFS, please do take part now to help us decode ME at www.decodeme.org.uk/portal.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 4 hacks to get teens off the sofa and get active – as study warns of heart damage Taking adult education classes may lower risk of dementia, study suggests Indiyah Polack: I didn’t want to go on Love Island because of my acne

From finely cut bangs to platinum tresses, Kim Kardashian isn’t anything if not daring when it comes to experimenting with her hair. The 42-year-old style muse may have just pulled off her most jaw-dropping transformation yet as she posed for the CR Fashion Book 2023 cover with a buzzed head and thinly arched brows. Creative director Youssef Marquis reimagined Kardashian’s long dark locks more frayed and short-ended. The reality star’s predictable sleek, fine appearance was replaced by a rugged and bare style, juxtaposing the very image Kardashian has created for herself. In the photo shoot, Kardashian can be seen stripped of colour and accessories, with only her barely-there brows and almost gone head of hair giving her a bit of edge. Smears of dirt wrapped the lauded A-lister’s arms, chest, and white tank top. Other images displayed the businesswoman with angeled readers, a thick stroke of black eyeshadow under her waterline, a C-cut of makeup drooping down her cheek to the edge of her mouth, and dangling a cigarette by her teeth as she focused on a camera ahead. Her clothing switched from a fitted tank to an oversized sweater and a thin button-down jumper. In the world of CR, Kardashian is both the spectacle and the seer. A soft shimmery gloss coated her eyelids as the only apparent makeup on her face. The cover said, “Kim Kardashian by Nadia Lee Cohen.” On social media, the new look has proven to be a hit among Kardashian’s fans. “Umm, this is iconic,” one fan wrote in the comments under Kardashian’s Instagram post, while another said: “Sooo cool, I love this look on you.” The Skims founder also reflected on her first encounter with the magazine’s Editor-in-Chief, Carine Roitfeld. “I had always heard you were the most stylish person on the planet, and I had your books at my house. We met when I was pregnant with North, and you asked to do my first fashion cover,” she remarked. “I was freaking out. Karl [Lagerfeld] shot it, Riccardo [Tisci] art directed it, and you styled it. I was so nervous and so excited all at the same time.” Kardashian allowed her cover feature for CR Fashion Book to play out exactly as the team had envisioned. “I show up on set and the makeup artist only had two products,” the entrepreneur confessed. “And I was low-key freaking out but obviously trusted your plan.” Labelled as “the muse of our generation,” the Skkn creator’s account on parenting, social justice, and internal reflection was analysed in her exclusive sit down with Roitfeld. “If there was a goddess who presided over social media, reality television, fashion, or entrepreneurship, Kim Kardashian could arguably hold any and all of those titles,” her feature read. The fashion fanatic first posed for the cover of CR with their Fall/Winter 2013 Issue 3. Here, her spirit was pictured differently. Kardashian’s fluffy eyebrows remained as they were, and her satiny straight hair stayed. Read More Kim Kardashian wears Chanel Barbie necklace in new Super Bowl ad with Usher Kim Kardashian makes her scripted TV debut in American Horror Story. Here’s how to watch and stream online Kim Kardashian faces backlash for posing in Balenciaga after condemning brand over child scandal Kim Kardashian wears Chanel Barbie necklace in new Super Bowl ad with Usher Caitlyn Jenner claims Kim Kardashian ‘calculated how to be famous’ in early career Kim Kardashian faces backlash for posing in Balenciaga a year after campaign scandal

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Whether you’re a frequent reader of Refinery29 or are proudly well-versed in the world of SPF, you’ve definitely heard of Supergoop!. (The exclamation point is a fraction of the enthusiasm the brand has for all things sun safety.) While Supergoop! has a smattering of bonafide bestsellers (ever heard of Unseen Sunscreen?), the brand’s SPF œuvre is secretly full of hidden gems. I would know, because my own sunscreen wardrobe is positively stacked.

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Iowa Gov. Kim Reynolds said on Tuesday that plans are in progress to appeal a temporary block on the state's new, restrictive abortion law, previewing a likely emotional court battle that could take months to resolve. Reynolds told reporters at the Iowa Capitol that her staff is working with lawyers in Attorney General Brenna Bird's office to work out the details, so “it's just a matter of time,” she said. The Republican-controlled Legislature approved the measure to ban most abortions after about six weeks of pregnancy during a special session last week, and it went into effect Friday, immediately after Reynolds signed it. The ACLU of Iowa, Planned Parenthood North Central States and the Emma Goldman Clinic launched a legal challenge and on Monday, Judge Joseph Seidlin granted their request to pause the law as the courts assess its constitutionality. Abortion providers said they scrambled to fit in as many appointments as possible before the governor signed the bill, making hundreds of calls to prepare patients for the uncertainty and keeping clinics open late. After the ruling, providers at Planned Parenthood and the Emma Goldman Clinic indicated they were relieved but conscious of the long legal fight ahead. “I think the bill that we passed is constitutional, especially with the changes that we’ve seen," said Reynolds, who alluded to the Iowa Supreme Court and the U.S. Supreme Court reversing previous rulings that affirmed a woman's fundamental right to abortion. “We passed it, it went into law, and for three days we were saving babies,” she said. “I think the right to life is the most important right that we have.” Read More Ukraine war’s heaviest fight rages in east - follow live Charity boss speaks out over ‘traumatic’ encounter with royal aide

LOS ANGELES--(BUSINESS WIRE)--May 25, 2023--

George Russell cannot complain about Lewis Hamilton receiving preferential treatment due to his higher status at Mercedes, says ex-F1 driver Anthony Davidson. The Mercedes pair, who are coming to the end of their second season together, jostled for position on track at the Japanese Grand Prix on Sunday. With Hamilton on fresher tyres, he made the move stick – but Russell was irritated that his request for his team-mate to give him DRS to help defend from Carlos Sainz fell on deaf ears. Hamilton, who has won six of his seven world titles at Mercedes, has been with the Silver Arrows since 2013 and Davidson insists it is no surprise that the 38-year-old still has a higher status in the garage than his compatriot Russell. “There’s definitely a hierarchy in that team,” Davidson told Sky Sports’ F1 Podcast. “And rightly so. Lewis has earned that status in that team as a seven-time world champion and George can’t argue against that. George is still the understudy and he’s doing a very good job on those occasions where he’s got the speed over Lewis to really take the fight to him. “But he’s doing it in such a ‘George Russell polite way’ which is quite humorous to watch because I know inside the car, he’ll be fuming and steaming. ‘And that’s why we see the near misses, the drivers coming almost to blows, almost to contact, but then he’s a good boy on the radio, he’s very British about it.” Russell beat Hamilton in the championship standings last year while also claiming Mercedes’ only victory in 2022, when he secured his first F1 win at the Sao Paulo Grand Prix. However, Hamilton is 75 points clear of Russell this season with six races to go. “He [Russell] knows he’s got the speed, we all see it as well from the outside,” Davidson added. “Lewis is getting his elbows out when he needs to. I’m really intrigued by this battle and watching George develop as a driver and watching Lewis in his latter years in his career.” Mercedes are still searching for their first win in 2023; a goal they will continue to strive for at the next race in Qatar (6-8 October) where Max Verstappen can claim his third-straight drivers’ title. Read More Nyck de Vries makes racing return after F1 exit The rise of Oscar Piastri: A genuine rival for Lando Norris at last Lewis Hamilton frustrated by Mercedes strategy in Japanese Grand Prix Nyck de Vries makes racing return after F1 exit Aston Martin’s Jessica Hawkins becomes first woman to test F1 car since 2018 Jessica Hawkins becomes first woman to drive F1 test in five years

Bradley Cooper’s Leonard Bernstein drama “Maestro,” Sofia Coppola’s Priscilla Presley movie, Michael Mann’s “Ferrari,” David Fincher’s “The Killer” and Ava DuVernay’s “Origin” will be making their world debuts at the Venice International Film Festival this fall

Wildlife officials are trying to capture a wayward sea otter that has been wrestling surfboards away from surfers and aggressively approaching kayakers off the coast of Santa Cruz, California